Tuberculosis (TB) is now a global public health problem that has been exacerbated by the emergence of multiand extensively-drug resistant (MDR and XDR, respectively) strains of Mycobacterium tuberculosis. There have been claims in the region by Traditional Medicine Practitioners (TMPs) about being able to treat the symptoms of TB, but their work lacked proper documentation. A structured questionnaire was used to test the ability of (TMPs) to diagnose and treat symptoms of TB; the medicinal plants used treat TB symptoms, as well as the influence of socio-economic and cultural factors on the indigenous communities' choice of treatment. A total of 99 TMPs and 22 TB patients were interviewed. Over 30 medicinal plants were mentioned as being used to treat symptoms of TB, an indication of wide knowledge on management of TB in the region. Treatment costs were found to influence the patients' choice of TB treatment and a large proportion of the TMPs were found to be of advanced age (60-80 years of age). The conclusion was that TMPs have reasonable knowledge about TB and its management. There is urgent need to tap the indigenous knowledge from the custodians and scientifically validate it for future drug development.

Background: Malnutrition is an important clinical outcome amongst HIV patients in developing countries and in Uganda, there is scarcity of information on its prevalence and risk factors amongst HIV adult patients. Methods: A cross-sectional study amongst 253 HIV patients in Bushenyi district assessed their nutritional status using the body mass index (BMI) and mid-upper arm circumference (MUAC), and a questionnaire was used to identify major risk factors. Results: The mean age of the study participants was 38.74 ± 0.80 yrs, while females and males were 52.2% and 47.8% respectively. Prevalence of malnutrition was 10.28% (95% CI: 6.82 – 14.69) in the study. Major socio-economic factors associated with malnutrition were being female, unemployed, dependent and with many family members. Patients with op- portunistic infections, low adherence to HAART, and stage of HIV/AIDS had a higher risk of malnutrition. Discussion: In rural communities, a majority of malnourished patients are elderly and these were identified as priority groups for HIV outreach campaigns. The current policy of prioritizing children and women is outdated due to changing disease dynamics, thus showing a need to revise extension service provision in rural communities. Conclusion: Malnutrition is a threat in HIV adult patients in rural communities of Uganda. Keywords: Malnutrition; HIV adult patients; Bushenyi district; Uganda.

Background The COVID-19 pandemic has disrupted health care access in many countries. The aim of this study was to explore factors that influenced access and utilisation of sexual and reproductive health services among Ugandan youths during the COVID-19 pandemic lockdown. Methods This was across-sectional study carried out from April 2020 to May 2020 in Uganda. A questionnaire was administered online to participants aged 18 to 30 years. Subjects were recruited using a snowballing approach. STATA version 14.2 was used for statistical analysis.Results Of 724 participants, 203 (28%) reported that they did not have access to information and/or education concerning sexual and reproductive health (SRH). More than a quarter of the participants (26.9%, n=195) reported that testing and treatment services of sexually transmitted infections were not available during the lockdown. 27.2% could not obtain contraceptive supplies. Access to HIV services and menstrual supplies were also impaired. Lack of transportation was the commonest factor cited as limiting access to SRH services during the lockdown (68.7%), followed by the long distance from home to SRH facilities (55.2%), high cost of services (42.2%) and the curfew (39.1%). Sexually transmitted infections were the commonest SRH problems related to SRH during the lockdown (40.4%) followed by unwanted pregnancy (32.4%) and sexual abuse (32.4%). Marital, educational, and employment status were significantly correlated with the reported experiences of the participants. Conclusion Access to SRH information and services for Ugandan youths was restricted during the COVID-19 lockdown and may have increased the incidence of poor SRH outcomes. Lack of transportation, distance to health facilities, and high cost of services were important limiting factors. The Government and other stakeholders should incorporate SRH among the priority services to be preserved during future outbreaks.

We report here, the results from total crude methanol extract as well as serial ether, chloroform, and methanol extracts of the root of Cryptolepis sanguinolenta (Lindl) Schltr that were screened against three strains of Mycobacterium tuberculosis. The strains used included the pan sensitive H37Rv, the rifampicin-resistant TMC-331 and a wild strain of Mycobacetrium avium (MA) isolated from a Ugandan patient. The disc diffusion method was used for susceptibility tests on solid Middle brook 7H10 while the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by the microtitre plate method using Middle brook 7H9 broth. We report that the total crude methanol extract showed the highest activity against H37Rv and TM-331 with complete clearance of quadrants at 50 mg/ml and zones of inhibition of 10.0 to 11 mm at 25 mg/ml concentration although it was not effective against M. avium. The corresponding MIC values were 1.17 mg/ml for H37Rv and 1.56 mg/ml for TMC-331. The values for isoniazid were 0.25 and 9.38 µg/ml for H37Rv and TMC-331, respectively, while for rifampicin the MIC value was 0.25 µg/ml for H37Rv but it was not active on TMC-331. Acute toxicity test gave an LD 50 of 758.5 mg/kg body weight while the phytochemical analysis showed the presence of alkaloids, tannins and flavonoids.

IntroductionMasters Students are major stakeholders in undergraduate medical education but their contribution has not been documented in Uganda. The aim of the study was to explore and document views and experiences of undergraduate students regarding the role of masters students as educators in four Ugandan medical schools.MethodsThis was a cross-sectional descriptive study using qualitative data collection methods. Eight Focus Group Discussions were conducted among eighty one selected preclinical and clinical students in the consortium of four Ugandan medical schools: Mbarara University of Science and Technology, Makerere College of Health Sciences, Gulu University and Kampala International University, Western Campus. Data analysis was done using thematic analysis. Participants’ privacy and confidentiality were respected and participant identifiers were not included in data analysis.ResultsUndergraduate students from all the medical schools viewed the involvement of master's students as very important. Frequent contact between masters and undergraduate students was reported as an important factor in undergraduate students’ motivation and learning. Despite the useful contribution, master’ students face numerous challenges like heavy workload and conflicting priorities.ConclusionAccording to undergraduate students in Ugandan medical schools, involvement of master's students in the teaching and learning of undergraduate students is both useful and challenging to masters and undergraduate students. Masters students provide peer mentorship to the undergraduate students. The senior educators are still needed to do their work and also to support the master's students in their teaching role.

BackgroundThe COVID-19 pandemic has caused a wide range of disruptions in health care access in many low and middle income countries. The aim of this study was to explore factors that influenced access and utilisation of sexual and reproductive health services among Ugandan youths during the COVID-19 pandemic lockdown. MethodsThis was an online cross-sectional study carried out from April 2020 to May 2020 in Uganda. An online questionnaire was used and participants aged 18years to 30 years were recruited using the snowballing approach. The statistical analysis was done using STATA version 14.2.Results Out of 724 participants, 203 (28%) reported not having information and/or education concerning sexual and reproductive health (SRH). About a quarter of the participants (26.9%, n=195) reported not having access to testing and treatment services of sexually transmitted infections during the lockdown. Lack of transport means was the commonest (68.7%) limiting factor to accessing SRH services during the lockdown followed by the long distance from home to SRH facilities (55.2%), high cost of services (42.2%) and curfew conditions (39.1%). Sexually transmitted infections were the commonest (40.4%) problems related to SRH during the lockdown followed by unwanted pregnancy (32.4%) and sexual abuse (32.4%). Limiting factors were more prevalent among the co-habiting youths [CPR: 1.3 (1.13-1.49) and APR:1.2 (1.06-1.41)] followed by unemployed [CPR: 1.3 (1.09 - 1.53) and APR:1.2 (1 - 1.42)] and non-salaried [APR:1.2 (1- 1.42)] than other participants. The bivariate and multivariate regression analyses indicate that problems were more prevalent among the co-habiting youths [CPR: 2.7 (1.88 - 3.74) and APR: 2.3 (1.6 - 3.29)] followed by the unemployed [CPR: 2 (1.27 - 3.2) and APR: 1.6 (1.03 - 2.64)] than in other categories. ConclusionThe findings of this study show that Ugandan youths had limited access to SRH information and services during the COVID-19 lockdown. Cohabiting and unemployed youths were the most affected by problems related to SRH. Lack of transport means and high cost of services were the major limiting factors to access SRH services among the youths. The findings call for concerted efforts from the Government and other stakeholders to incorporate SRH among the priority services when designing responses to any outbreak crisis.

IntroductionSexual and Reproductive Health access to Information services is still a pressing need for youth in Uganda even during the COVID-19 pandemic, which has disrupted health care access in many countries. The aim of this study was to explore the challenges in access and utilization of sexual and reproductive health services as faced by youth during the COVID-19 pandemic lockdown in Uganda.MethodsThis was a cross-sectional study carried out from 28th April 2020 to 11th May 2020 in Uganda. An online questionnaire was disseminated to youth aged between 18 and 30 years over a period of 14 days. The snowball sampling method was used to recruit participants. STATA version 14.2 was used for statistical analysis.ResultsOf 724 participants, 203 (28%) reported that they did not have access to information and/or education concerning sexual and reproductive health (SRH). More than a quarter of the participants (26.9%, n = 195) reported that testing and treatment services of sexually transmitted infections were not available during the lockdown, and 27.2% could not obtain contraceptive supplies. Access to HIV/AIDS care services and menstrual supplies was also impaired. Lack of transportation was the commonest factor cited as limiting access to SRH services during the lockdown (68.7%), followed by the long distance from home to SRH facilities (55.2%), high cost of services (42.2%) and the curfew (39.1%). Sexually transmitted infections were the commonest SRH problems related to SRH during the lockdown (40.4%) followed by unwanted pregnancy (32.4%) and sexual abuse (32.4%). Marital, educational, and employment status were significantly correlated with the reported experiences of the participants.ConclusionAccess to SRH information and services for Ugandan youth was restricted during the COVID-19 lockdown and leaving them vulnerable to various SRH risks and adverse outcomes. Lack of transportation, long distances to health facilities, and high cost of services were important limiting factors. The Government and other stakeholders should incorporate SRH among the priority services to be preserved during future outbreaks.

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