Local Management of Tuberculosis by Traditional Medicine Practitioners in Lake Victoria Region

Orodho, John Aluko; Kirimuhuzya, Claude; Otieno, Joseph; Magadula, Joseph J.; Okemo, P. O.

doi:10.2174/1876391x01103010001

Cited by 13 publications

(32 citation statements)

References 10 publications

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“…Engl. Acanthaceae Matovu, Itojo Herb Roots Uganda, Kenya [ 10 , 12 ] Achyranthes aspera L. Amaranthaceae Muhurura Herb Flower Uganda [ 10 ] Achyrospermum carvalhoi Gürke Lamiaceae Kanyamafundo Shrub Leaves Uganda [ 10 ] Acokanthera friesiorum Apocynaceae Chipilikwa (Samburu) Tree Leaves Kenya [ 29 ] Adenia gummifera Passifloraceae Chepnyalildet (Nandi) Climber Roots Kenya [ 31 ] Adhatoda engleriana Lindau C.B. Clarke Acanthaceae Iringoringo (Chagga) Herb Roots Tanzania [ 32 ] Ageratum conyzoides L. Asteraceae Namirembe (Luganda) Herb Whole plant Uganda [ 7 ] Alangium chinense (Lour.)…”

Section: Resultsmentioning

confidence: 99%

“…Harms Cornaceae Omusiisa (Luganda) Herb Stem bark Uganda [ 7 ] Albizia anthelmitica Fabaceaa Lamurtana (Samburu) Tree Stem bark Kenya [ 29 ] Albizia coriaria Welw. Ex Oliv Fabaceae Mugavu (Luganda), Etek (Lango), Musita (Lusoga), Omusesa (Runyangkore), Omubele (Wanga) Tree Stem bark Uganda, Kenya [ 7 – 10 , 12 , 33 ] Albizia species Fabaceae Ennongo (Luganda) Tree Stem bark Uganda [ 7 ] Albizia versicola Fabaceae Not reported Tree Leaves Tanzania, Kenya [ 12 ] Albizia zygia (DC.) Macbr.…”

Section: Resultsmentioning

confidence: 99%

“…Adams Asteraceae Makaayi (Luganda) Emaruoit Herb Root bark, Leaves Uganda [ 7 , 10 ] Aspilia pluriseta Schweinf. Asteraceae Rirangera Herb Roots Kenya [ 28 ] Azadirachta indica L. Meliaceae Muarubaini (Kamba) Tree Seeds Kenya [ 12 ] Azadirachta indica A. Juss. Meliaceae Neem tree (Luganda) Tree Leaves, stem bark Uganda [ 7 , 10 ] Balanites aegyptiaca (L.) Delile Zygophyllaceae Olngosua (Maasai), Ekorete Shrub Stem bark Tanzania, Kenya; Uganda [ 10 , 12 ] Bersama abyssinica Fres.…”

Section: Resultsmentioning

confidence: 99%

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Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

et al. 2020

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Objective Many studies on the treatment of tuberculosis (TB) using herbal medicines have been undertaken in recent decades in East Africa. The details, however, are highly fragmented. The purpose of this study was to provide a comprehensive overview of the reported medicinal plants used to manage TB symptoms, and to analyze scientific reports on their effectiveness and safety. Method A comprehensive literature search was performed in the major electronic databases regarding medicinal plants used in the management of TB in East Africa. A total of 44 reports were retrieved, and data were collected on various aspects of the medicinal plants such as botanical name, family, local names, part(s) used, method of preparation, efficacy, toxicity, and phytochemistry. The data were summarized into percentages and frequencies which were presented as tables and graphs. Results A total of 195 species of plants belonging to 68 families and 144 genera were identified. Most encountered species were from Fabaceae (42.6%), Lamiaceae (19.1%), Asteraceae (16.2%), and Euphorbiaceae (14.7%) families. Only 36 medicinal plants (18.5%) have been screened for antimycobacterial activity. Out of these, 31 (86.1%) were reported to be bioactive with minimum inhibitory concentrations ranging from 47 to 12,500 μg/ml. Most tested plant extracts were found to have acceptable acute toxicity profiles with cytotoxic concentrations on normal mammalian cells greater than 200 μg/ml. The most commonly reported phytochemicals were flavonoids, terpenoids, alkaloids, saponins, cardiac glycosides, and phenols. Only Tetradenia riparia , Warburgia ugandensis , and Zanthoxylum leprieurii have further undergone isolation and characterization of the pure bioactive compounds. Conclusion East Africa has a rich diversity of medicinal plants that have been reported to be effective in the management of symptoms of TB. More validation studies are required to promote the discovery of antimycobacterial drugs and to provide evidence for standardization of herbal medicine use.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

et al. 2020

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“…The continual resistance of M. tuberculosis to commonly prescribed antimicrobials has made people fall back on herbal medicines for various therapeutic purposes (Orodho et al. 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Ethno-medicinal documentation of polyherbal medicines used for the treatment of tuberculosis in Amathole District Municipality of the Eastern Cape Province, South Africa

Famewo

Clarke

Afolayan

2017

Pharmaceutical Biology

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Context: Tuberculosis (TB) has remained a devastating global public health problem. In the continuing search for effective treatment, polyherbal remedies used as alternative medicines in the Eastern Cape Province of South Africa were surveyed.Objective: The survey collected information and documents the list of ingredients such as the name of the plants used including the non-herbal inclusions, type and dosage of polyherbal formulations used for the treatment of TB.Materials and methods: The survey was conducted over a period of 6 months using semi-structured questionnaires amidst informal conversations with the traditional healers in five communities in the study area. The chosen study area is the third infected Province with TB in South Africa.Results: A total of nine polyherbal preparations were collected. Information on the parts of the plant used, mode of preparation and the dosage used were documented. In total, the herbs belong to 20 families of which Apiaceae, Liliaceae, Strychnaceae, Rutaceae and Hypoxidaceae are the most prominent. However, members of Apiaceae were commonly mentioned for the preparation of the remedies. The two most frequently used plants were Allium sativum L. (Liliaceae) and Strychnos decussata (Pappe) Gilg. (Strychnaceae). Rhizome was the commonest parts used, followed by the roots and barks.Conclusions: This paper provides significant ethno-medicinal information on polyherbal medicines used for the treatment of TB in the study area. The therapeutic claims made on medicinal plants used for the preparations are well supported by the literature, with many of the species having antimicrobial properties.

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“…The emergence of multi-drug resistant tuberculosis (MDRTB), extensively drug resistant tuberculosis (XDRTB), and totally drug resistant tuberculosis (TDR) has exacerbated the global health problem [ 9 , 10 ]. Due to the high resistance of M. tuberculosis to commonly prescribed antimicrobials, relatively high cost and limited access to synthetically derived drugs, most communities especially in Africa still rely on the use of polyherbal medicine for the treatment of their ailments [ 11 , 12 ]. Yet, these medicines have been reported to contain a number of microbial and heavy metal contaminants [ 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of bacterial contaminants in polyherbal medicines used for the treatment of tuberculosis in Amatole District of the Eastern Cape Province, South Africa, using rapid 16S rRNA technique

Famewo

Clarke

Afolayan

2016

J Health Popul Nutr

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BackgroundPolyherbal medicines are used for the treatment of many diseases in many African and Asian communities. With the increasing use of these remedies, several investigations have shown that they are associated with a broad variety of residues and contaminants. This study investigates the presence of bacteria in the polyherbal medicines used for the treatment of tuberculosis (TB) in the Eastern Cape Province of South Africa.MethodsBacterial DNA was extracted from the polyherbal medicines, and a fragment of the bacterial 16S rRNA gene was amplified by PCR with universal primers 27F and 518R. The amplicons were visualised on agarose gel electrophoresis, followed by end repair and adaptor ligation. They were further purified and quantified using Library Preparation kit NEBNext® UltraT DNA Library Prep Kit for Illumina, and the amplicons were run on illumina’s MiSeq platform.ResultsDifferent bacterial species were identified in all each of the polyherbal medicines. Generally, the most prominent and common bacteria recovered from all the samples were Bacillus sp., Enterobacter sp., Klebsiella sp., Rahnella sp., Paenibacillus sp., Clostridium sp. and Pantoea sp. Others are Pseudomonas sp., Raoultella ornithinolytica, Salmonella enterica and Eubacterium moniliforme.ConclusionsThis study, thus, revealed the presence of pathogenic and non-pathogenic bacteria in the polyherbal medicines used for the treatment of tuberculosis in the study area. The implications of the findings are discussed in relation to the health care of the patients of tuberculosis in the study area, having in mind that they are immunocompromised individuals.

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Local Management of Tuberculosis by Traditional Medicine Practitioners in Lake Victoria Region

Cited by 13 publications

References 10 publications

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Ethno-medicinal documentation of polyherbal medicines used for the treatment of tuberculosis in Amathole District Municipality of the Eastern Cape Province, South Africa

Identification of bacterial contaminants in polyherbal medicines used for the treatment of tuberculosis in Amatole District of the Eastern Cape Province, South Africa, using rapid 16S rRNA technique

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