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Results: Within 4 weeks after inclusion a CCI>0.4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1,-2,-3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI>0.4. Similarly, none of the analysed proteins was found to be associated with IAC with the exception of lower MBL levels (HR 0.74, p=0.02) at study entry.However, there was no association of MBL deficiency (<0.5 µg/ml), MBL2 haplo-or genotypes with IAC. Conclusion:Lectin pathway protein levels and MBL2 genotype investigated in this study were not associated with heavy Candida colonization or IAC in a cohort of high-risk ICU patients. 4Introduction: