Pattern Recognition Molecules of the Lectin Pathway—Screening of Patients with Suspected Immunodeficiency

Jørgensen, Clara; Jensen, Lisbeth; Christiansen, Mette; Bjerre, Mette; Jensen, Jens Magnus Bernth; Thiel, Steffen

doi:10.1007/s10875-019-00675-8

Cited by 9 publications

(17 citation statements)

References 32 publications

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“…We have previously found higher levels of CRP in CVID patients compared with healthy individuals 23 . Using the earlier published data set for CRP in the patient samples, 23 we found that CRP correlated positively with MAp19 in both CVID patients ( r = 0.51, P < 0.001) and healthy individuals ( r = 0.26, P < 0.001). We also observed a positive correlation among healthy individuals between MASP‐3 and CRP ( r = 0.26, P < 0.001); this was not observed for patients with CVID.…”

Section: Resultsmentioning

confidence: 56%

“…The growing understanding of the complex interactions of the immune system urged us to explore the levels of the innate immune system proteins, MASPs and MAps, in patients with CVID and other patients tested for primary immunodeficiency diseases. Together with a previous study, 23 the present study provides a complete description of the levels of all 10 lectin pathway proteins in patients referred for clinical investigation of immunodeficiency. To the best of our knowledge, this is the first complete report of the lectin pathway in patients with CVID.…”

Section: Discussionmentioning

confidence: 78%

“…The other patient groups, which were included and analysed in parallel, served as additional controls. Genetic analyses were not available on all patients, but genetic deficiencies determined for some of the patients have previously been described 23 …”

Section: Methodsmentioning

confidence: 99%

“…We have previously investigated the PRMs of the lectin pathway in CVID patients in a cohort of suspect immunodeficiency patients 23 . Our aim of the present study was to expand this work by focusing on MASPs and MAps of the lectin pathway of complement.…”

Section: Introductionmentioning

confidence: 99%

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Low levels of the innate immune system proteins MASP‐2 and MAp44 in patients with common variable immunodeficiency

et al. 2022

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Infections are frequent causes of contact with the healthcare system. Some patients experience an exceptionally high burden of infections that may result from an underlying primary immune defect (PID). Common variable immunodeficiency (CVID) is among the most frequent significant PID diagnoses, with a prevalence of approximately 1:25 000 in adults. 1 According to the American Academy of Allergy, Asthma & Immunology and the American College of Allergy, Asthma & Immunology, CVID is defined as a marked decrease in plasma IgG and at least one of the classes IgM or IgA, and fulfilment of the following three criteria: (i) onset of immunodeficiency after age 2 years, (ii) poor ability to produce antibody response to antigenic challenge and (iii) defined causes of hypogammaglobulinemia have been excluded. 2 Common features are B cell perturbations and antibody deficiency,

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Section: Resultsmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low levels of the innate immune system proteins MASP‐2 and MAp44 in patients with common variable immunodeficiency

et al. 2022

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“…In an investigation of the roles of lectin pathway components in 332 patients with recurrent infections, serum CL-L1 levels quantified by time-resolved immunofluorometric assay in 25 patients with abscesses were 15% higher than in healthy people ( 81 ). However, low serum CL-L1 levels are associated with the increased the risk of nosocomial infections in children ( 82 ).…”

Section: Role Of Collectins In Skin Immune Homeostasismentioning

confidence: 99%

A Plausible Role for Collectins in Skin Immune Homeostasis

Xiao

Xia

2021

Front. Immunol.

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The skin is a complex organ that faces the external environment and participates in the innate immune system. Skin immune homeostasis is necessary to defend against external microorganisms and to recover from stress to the skin. This homeostasis depends on interactions among a variety of cells, cytokines, and the complement system. Collectins belong to the lectin pathway of the complement system, and have various roles in innate immune responses. Mannose-binding lectin (MBL), collectin kidney 1, and liver (CL-K1, CL-L1) activate the lectin pathway, while all have multiple functions, including recognition of pathogens, opsonization of phagocytosis, and modulation of cytokine-mediated inflammatory responses. Certain collectins are localized in the skin, and their expressions change during skin diseases. In this review, we summarize important advances in our understanding of how MBL, surfactant proteins A and D, CL-L1, and CL-K1 function in skin immune homeostasis. Based on the potential roles of collectins in skin diseases, we suggest therapeutic strategies for skin diseases through the targeting of collectins and relevant regulators.

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Pathogenic bacteria defense and complement activation function analysis of Collectin-10 from Hexagrammos otakii

Zha

Zhang

Zhong

et al. 2023

Fish & Shellfish Immunology

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Pattern Recognition Molecules of the Lectin Pathway—Screening of Patients with Suspected Immunodeficiency

Cited by 9 publications

References 32 publications

Low levels of the innate immune system proteins MASP‐2 and MAp44 in patients with common variable immunodeficiency

Low levels of the innate immune system proteins MASP‐2 and MAp44 in patients with common variable immunodeficiency

A Plausible Role for Collectins in Skin Immune Homeostasis

Pathogenic bacteria defense and complement activation function analysis of Collectin-10 from Hexagrammos otakii

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