Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland

Osthoff, Michael; Wójtowicz, Agnieszka; Tissot, F; Jørgensen, Clara; Thiel, Steffen; Zimmerli, Stephan; Marchetti, Oscar; Khanna, Nina; Bochud, Pierre–Yves; Trendelenburg, Marten; Bregenzer, Thomas; Conen, Anna; Fankhauser, Hans; Flückiger, Ursula; Frei, Reno; Heininger, Ulrich; Hertel, Roland; Franciolli, Mario; Giovanni, Ospedale San; Dolina, Marisa; Rothen, Madeleine; Dubuis, Olivier; Tarr, Philip E.; Graf, S.; Fleisch, Felix; Risch, Martin; Ritzler, Eva; Chuard, Christian; Erard, Véronique; Fracheboud, Dominique; Emonet, Stéphane; Genné, Daniel; Lienhardt, Reto; Chave, Jean-Philippe; Andreutti-Zaugg, Corinne; Gallusser, A.; Gräber, Peter; Monotti, R.; Bernasconi, Enos; Krause, Martín; Herzog, Karin; Piso, R.; Schibli, Urs; Bally, Frank; Troillet, Nicolas; Tissière, Lysiane; Boggian, Katja; Bruderer, Thomas; Gubler, Jacques; Eich, Gerhard; Berger, Christoph

doi:10.1016/j.jinf.2015.12.011

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…While these results identify the ficolins as PRRs that contribute to host defence against A fumigatus , other reports show that serum levels of ficolins are not associated with intra‐abdominal Candida albicans infection in high‐risk intensive care patients 35 . Therefore, it remains unclear whether the protective role of ficolins is directed solely against Aspergillus species or pathogenic fungi in general.…”

Section: Ficolinsmentioning

confidence: 73%

Fungal recognition by mammalian fibrinogen‐related proteins

Pilecki

Møeller

2020

Scand J Immunol

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Fungi are ubiquitous eukaryotic microorganisms present in virtually all environmental habitats. Although rarely pathogenic to the healthy population, many fungal species are capable of causing human disease in immunocompromised individuals. Thus, fungal infections remain a significant cause of morbidity and mortality, with rising prevalence accompanying the worldwide increase in immunosuppressionbased therapies. Therefore, better understanding of the mutual interactions between the protective host mechanisms and the invading fungi remains of critical importance. The innate immune system constitutes the first line of defence against exogenous insults. The innate antifungal immunity is mediated through recognition of specific pathogen-associated molecular patterns (PAMPs) by a broad panel of host pattern recognition receptors (PRRs), responsible for mounting adequate protective responses. In this review, we describe fungal PAMPs as well as a selection of PRRs able to recognize them. We focus on the members of the fibrinogen-related domain (FReD) protein family that have been shown to recognize fungi-derived molecules: ficolins, fibrinogen C domain containing 1 (FIBCD1) and tenascin-C. We describe their structure, their binding targets and their established as well as putative biological functions related to fungal recognition and immunity. F I G U R E 1 The fungal cell wall and exposure of PAMPs during fungal cell transitions. A, Schematic representation of the fungal cell wall. The outer cell wall primarily composed of mannoproteins (blue) shields the inner cell wall composed of glucans (red) and chitin (yellow) from recognition by host immunity. B, Schematic representation of fungal yeast cell division. During fungal cell division and in budding scars after division, the inner cell wall components (glucans and chitin) are exposed to the environment and can be recognized by the host. C, Representation of conidia, germination and growth of germ tubes. During germination (swollen conidia) and formation of germ tubes, the inner cell wall components are exposed to the environment and can be recognized by the host. D, Schematic representation of filamentous growth of hyphaeforming fungi. During formation and growth of hyphae, the inner cell wall components may be exposed to the environment and potentially recognized by the host How to cite this article: Pilecki B, Moeller JB. Fungal recognition by mammalian fibrinogen-related proteins.

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Section: Ficolinsmentioning

confidence: 73%

Fungal recognition by mammalian fibrinogen‐related proteins

Pilecki

Møeller

2020

Scand J Immunol

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“…2,38 In patients in a high-risk intensive-care unit no association between low or high MBL levels and Candida colonization and intra-abdominal candidiasis were found. 39 Thus, further studies are needed to address a possible causal association between MBL and fungal infections.…”

Section: Discussionmentioning

confidence: 99%

Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study

Gedebjerg

Thomsen

Kjærgaard

et al. 2021

Journal of Diabetes and its Complications

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“…Moreover, MBL deficiency is also associated with the development of abdominal yeast infection in peritonitis patients ( 216 ). However, MBL serum levels and genotypes were not associated with intra-abdominal candidiasis in a Swiss cohort ( 217 ). The RVVC patients also have a higher frequency of MBL2 mutations compared to both VVC and healthy groups ( 214 ).…”

Section: Opportunistic Invasive Mycosesmentioning

confidence: 95%

The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors

et al. 2018

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Fungi, usually present as commensals, are a major cause of opportunistic infections in immunocompromised patients. Such infections, if not diagnosed or treated properly, can prove fatal. However, in most cases healthy individuals are able to avert the fungal attacks by mounting proper antifungal immune responses. Among the pattern recognition receptors (PRRs), C-type lectin receptors (CLRs) are the major players in antifungal immunity. CLRs can recognize carbohydrate ligands, such as β-glucans and mannans, which are mainly found on fungal cell surfaces. They induce proinflammatory immune reactions, including phagocytosis, oxidative burst, cytokine, and chemokine production from innate effector cells, as well as activation of adaptive immunity via Th17 responses. CLRs such as Dectin-1, Dectin-2, Mincle, mannose receptor (MR), and DC-SIGN can recognize many disease-causing fungi and also collaborate with each other as well as other PRRs in mounting a fungi-specific immune response. Mutations in these receptors affect the host response and have been linked to a higher risk in contracting fungal infections. This review focuses on how CLRs on various immune cells orchestrate the antifungal response and on the contribution of single nucleotide polymorphisms in these receptors toward the risk of developing such infections.

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Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland

Cited by 6 publications

References 39 publications

Fungal recognition by mammalian fibrinogen‐related proteins

Fungal recognition by mammalian fibrinogen‐related proteins

Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study

The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors

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