ObjectiveTo develop a reliable and validated tool for prediction of spontaneous preterm birth (sPTB)

Landslide inventories are essential because they provide the basis for predictive landslide hazard and susceptibility assessments and because they allow for the manipulation and storage of temporal and spatial data. The National Landslide Database has been developed by the British Geological Survey (BGS). It is the most extensive source of information on landslides in Great Britain with over 15 000 records of landslide events each documented as fully as possible. This information is invaluable for planners and developers as it helps them investigate, avoid or mitigate areas of unstable ground in accordance with Government planning policy guidelines. Therefore, it is vital that the continual verification, collection and updating of landslide information is carried out as part of the Survey's 'National Capability' work. This paper describes the evolution from a static database to one that is continually updated forming part of a suite of national digital hazard products. The history of the National Landslide Database and associated Geographical Information System (GIS) is discussed, together with its application and future development.

One of the most difficult problems that confronts clinicians and medical professionals is how to apply ethical principles to real decisions affecting patients. In this even-handed book, Foster examines the three main approaches to moral decision-making: goal-based, duty-based and rights-based. She examines the underlying philosophical arguments behind each, their relative strengths and weaknesses, and how they can actually be applied. She also looks at the problematic boundaries where best practice ends and experimentation begins. Is it ethical to experiment with new cures on people who are probably dying anyway? And how do you assess quality of consent? This book provides a thorough, non-partisan grounding in what the ethical principles are and what informs them. It is an invaluable preparation both for a researcher being interviewed by an ethics committee and for the people sitting on the committee, and will be essential reading for all medical decision-makers.

Spontaneous preterm birth (sPTB) is a challenge in obstetrics today, and is the leading cause of neonatal morbidity and mortality. The ability to predict preterm birth had, until recently, been poor. The biomarker fetal fibronectin (fFN), found at the maternal-fetal interface, when present in high concentrations in cervicovaginal fluid, has been shown to increase the risk of sPTB in symptomatic and asymptomatic women. Recently, further research has been performed into the applicability of such a test to clinical practice, and its effects on management decisions and patient outcomes. Owing to its high negative predictive value, a negative fFN result has been shown to reduce unnecessary interventions, change patient management and reduce healthcare costs, by allowing early reassurance and return to normal care pathways, while care can be concentrated on those at risk. The development of a bedside quantitative fFN test has shown promise to further improve the positive predictive abilities of fFN, as have combined predictive models with cervical length and fFN.

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