2016
DOI: 10.1002/uog.14894
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Development and validation of a tool incorporating quantitative fetal fibronectin to predict spontaneous preterm birth in symptomatic women

Abstract: ObjectiveTo develop a reliable and validated tool for prediction of spontaneous preterm birth (sPTB)

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Cited by 38 publications
(45 citation statements)
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“…This is in accordance with the theory that fFN levels are increased in association with disruption between the choriodecidual fusion and imminence of labour [11]. Recently, Kuhrt et al [12] developed and validated a new predictive model for spontaneous threatened preterm labour in symptomatic women using a qfFN. The researchers assessed 382 pregnant women between 22 and 35 + 6 weeks of gestation, and the model was developed on the first 190 women and validated on the remaining 192.…”
Section: Discussionsupporting
confidence: 48%
“…This is in accordance with the theory that fFN levels are increased in association with disruption between the choriodecidual fusion and imminence of labour [11]. Recently, Kuhrt et al [12] developed and validated a new predictive model for spontaneous threatened preterm labour in symptomatic women using a qfFN. The researchers assessed 382 pregnant women between 22 and 35 + 6 weeks of gestation, and the model was developed on the first 190 women and validated on the remaining 192.…”
Section: Discussionsupporting
confidence: 48%
“…5961 In a pre-specified secondary analysis of a prospective blinded study, the positive predictive value for SPTB o 34 weeks gestation increased from 19%, 32%, 61%, and 75% with increasing thresholds (10, 50, 200, and 500 ng/mL, respectively). 59 The combination of quantitative FFN testing and CL assessment may further increase predictive value, but data remains limited to preliminary observational studies.…”
Section: Introductionmentioning
confidence: 99%
“…Quantitative fFN also helps identify those at low risk with a known short cervix (< 25 mm), with 90% of women delivering after 34 weeks' gestation if the fFN is < 10 ng/mL. Combining quantitative fFN with risk factors and cervical length provides exciting opportunities for tailoring prediction to the individual.…”
Section: Discussionmentioning
confidence: 99%
“…In asymptomatic high‐risk women, fFN has a negative predictive value for spontaneous preterm birth before 30 weeks of 98.6% and a positive predictive value of 13.6% (when using the conventional fFN threshold of 50 ng/mL). When combined with cervical length and clinical history, the predictive performance of fFN is enhanced further.…”
Section: Introductionmentioning
confidence: 99%