There has been increasing interest in wireless, miniaturized implantable medical devices for in vivo and in situ physiological monitoring. Here, we present such an implant that uses a conventional ultrasound imager for wireless powering and data communication and acts as a probe for real-time temperature sensing, including the monitoring of body temperature and temperature changes resulting from therapeutic application of ultrasound. The sub–0.1-mm3, sub–1-nW device, referred to as a mote, achieves aggressive miniaturization through the monolithic integration of a custom low-power temperature sensor chip with a microscale piezoelectric transducer fabricated on top of the chip. The small displaced volume of these motes allows them to be implanted or injected using minimally invasive techniques with improved biocompatibility. We demonstrate their sensing functionality in vivo for an ultrasound neurostimulation procedure in mice. Our motes have the potential to be adapted to the distributed and localized sensing of other clinically relevant physiological parameters.

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Four new metal-oragnic frameworks based on transition metals, namely [Mn2(μ2-H2O)2(H2L)2(CH3CN)2] (1), [Mn(L)0.5(phen)•0.5H2O] (2), [Co(H2O)2(L)0.5(bip)•H2O] (3) and [Co2(L)(bb)2•HbbBr] (4), (H4L = 5,5'-(1,4-phenylenebis(methyleneoxy))diisophthalic acid, bip = 3,5-bis(1-imidazoly)pyridine, phen = 1,10-phenanthroline, bb =...

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Objective There is heterogeneity in the prognosis of gastric cancers staged according to the tumornodes- metastasis (TNM) system. This study evaluated the prognostic potential of an immune score system to supplement the TNM staging system. Methods An immunohistochemical analysis was conducted to assess the density of T cells, B cells, and myeloid-derived suppressor cells (MDSCs) in cancer tissues from 100 stage IIIA gastric cancer patients; the expression of the high-mobility group protein B1 (HMGB1) was also evaluated in cancer cells. The relationship between the overall survival (OS), disease-free survival (DFS), and immunological parameters was analyzed. Results An immune score system was compiled based on the prognostic role of the density of T cells, B cells, MDSCs, and the expression of HMGB1 in cancer tissues. The median 5-year survival of this group of patient was 32%. However, the 5-year survival rates of 80.0%, 51.7%, 0%, 5.8%, and 0% varied among the patients with an immune score of 4 to those with an immune score of 0 based on the immune score system, respectively. Similarly, differences in DFS rates were observed among the immune score subgroups. Conclusions An immune score system could effectively identify the prognostic heterogeneity within stage IIIA gastric cancer patients, implying that this immune score system may potentially supplement the TNM staging system, and help in identifying a more homogeneous group of patients who on the basis of prognosis can undergo adjuvant therapy.

Solubilities, densities, and refractive indices of the two ternary systems (LiBO 2 + NaBO 2 + H 2 O) and (LiBO 2 + KBO 2 + H 2 O) at 298.15 K and 0.1 MPa were conducted with the method of isothermal solution saturation. The diagrams of solubilities, densities, and refractive indices were constructed using experimental data. They both contained one invariant point co-saturated with two salts, two biphasic regions, and one triphasic region. As the concentration of sodium metaborate (potassium metaborate) increases in solution, the density and refractive index change regularly and reach a maximum value at the invariant point. The densities and refractive indices change regularly with the sodium metaborate (potassium metaborate) concentration increasing in solution and reach the maximum value at the invariant point.

This paper explores the extent to which a solid-state transmitter can be miniaturized, while still using RF for wireless information transfer and working with power densities and operating voltages comparable to what could be harvested from a living system. A 3.1 nJ/bit pulsed millimeter-wave transmitter, 300 by 300 by 250 in size, designed in 32-nm SOI CMOS, operates on an electric potential of 130 mV and 3.1 nW of dc power. Farfield data transmission at 33 GHz is achieved by supply-switching an LC-oscillator with a duty cycle of . The time interval between pulses carries information on the amount of power harvested by the radio, supporting a data rate of 1 bps. The inductor of the oscillator also acts as an electrically small on-chip antenna, which, combined with millimeter-wave operation, enables the extremely small form factor.Index Terms-Antennas, low power design, monolithic integrated circuits, radio frequency oscillators. 1549-8328