Prognostic potential of an immune score based on the density of CD8+ T cells, CD20+ B cells, and CD33+/p-STAT1+ double-positive cells and HMGB1 expression within cancer nests in stage IIIA gastric cancer patients

Dong, Jun; Li, Jiao; Liu, Shiming; Feng, Xingyu; Shi, Chuncheng; Zhou, Zhiwei; Chen, Yingbo; Zhang, Xiaoshi

doi:10.21147/j.issn.1000-9604.2016.05.10

Cited by 13 publications

(11 citation statements)

References 36 publications

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“…Six studies reported the prognostic value of general TILs, [ 14 , 15 , 18 , 19 , 23 , 24 ] 9 studies about CD8 + T lymphocytes, [ 13 , 16 , 20 , 25 , 27 , 31 – 33 , 36 ] 14 studies about FOXP3 + T lymphocytes, [ 17 , 20 – 22 , 26 , 28 , 29 , 31 , 34 – 35 , 37 – 40 ] 2 about CD4 + T lymphocytes, [ 29 , 33 ] and 5 about CD3 + T lymphocytes. [ 12 , 20 , 28 , 30 , 32 ] Association between general TILs or its subsets and patients’ prognoses in each study was described in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Association between density of tumor-infiltrating lymphocytes and prognoses of patients with gastric cancer

Long

Liao

et al. 2018

Medicine

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Introduction:Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic significance in patients with gastric cancer. This study aims to investigate the association between density of TILs and prognoses of patients with gastric cancer.Methods:The relative studies of tumor-infiltrating lymphocytes in tumor tissue from patients with gastric cancer were systematically searched from PubMed and Embase until October 31, 2017. The pooled hazard ratios (HRs) and their 95% confidence intervals (95%CI) for overall survival (OS) were estimated.Results:Twenty-nine studies involving 4,942 patients were included into analyses. Subset of TILs included CD8+, CD3+, CD4+, and FOXP3+ T cell density. Results from meta-analyses revealed that high density of intratumoral CD8+ T cells (HR = 0.77, 95% CI 0.63–0.95) and CD3+ (HR = 0.62, 95% CI 0.49–0.77) were associated with significantly higher OS than those with low density in patients with gastric cancer. Moreover, a larger number of general TILs density also suggested a favorable prognosis (HR 0.75, 95% CI 0.67–0.84). However, patients with high density of intratumoral FOXP3+ T or CD4+ T cells were not statistically associated with higher or lower OS than those with low density (HR 1.41, 95% CI 0.97–2.05; HR = 0.86, 95% CI 0.47–1.57). Sample size and follow-up period seemed to influence study outcomes.Conclusion:The present study revealed that high density of intratumoral CD8+ and CD3+ T cells were associated with better OS in patients with gastric cancer.

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Section: Resultsmentioning

confidence: 99%

Association between density of tumor-infiltrating lymphocytes and prognoses of patients with gastric cancer

Long

Liao

et al. 2018

Medicine

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“…Table II summarized the characteristics of all included studies [ 14 – 31 ]. The summarizes should represented by summarized incorporated studies were published from 2003 to 2016 and conducted in China ( n = 6), Germany ( n = 1), Korea ( n = 6), Japan ( n = 3), America ( n = 1), and Italy ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis and experimental validation

Zhang¹,

Cao²,

Duan³

et al. 2020

aoms

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Introduction: We performed a meta-analysis and an experimental validation to investigate the association between tumor infiltrating lymphocytes (TILs) and the outcome of gastric cancer (GC) patients to provide prognostic indicators for clinical practice. Material and methods: The relative literature of TILs in tumor tissue from patients with gastric cancer was searched from PubMed, Embase, NIH databases, from April 2000 to 31 December 2016. Studies on the prognostic value of TILs as CD3+, CD4+, CD8+, GrB+, and FOXP3+ lymphocytes for GC were retrieved, and also the related references were traced as supplements. Independent screening documents, extracting information and evaluating quality were implemented independently by 2 evaluators according to the inclusion and exclusion criteria, which were then analyzed by meta-analysis using STATA version 12.0 software. Results: The results indicated that high levels of intratumoral CD8+, CD3+ and CD4+ T cell infiltration were associated with better overall survival(OS) in gastric cancer patients, while high density of intratumoral FOXP3+ T cells was not closely associated with a worse outcome. Additionally, in our study, higher density of granzyme B+ (GrB+) T cell infiltration indicated an optimistic prognosis, and infiltration of a larger number of general TILs also suggested a favorable prognosis by log-rank test analysis. Conclusions: This meta-analysis clarified that high levels of CD8+, CD3+, and CD4+ T cell infiltration in tumor tissue showed better OS in GC patients, whereas high density of FOXP3+ T cell infiltration may not be recognized as a negative prognostic factor. These results may provide some useful prognostic indicators for clinical application in gastric cancer.

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“…Lymphocyte-activation gene 3 (LAG3) is a transmembrane protein with structural homology to CD4 co-receptors [51]. It is found in activated CD4 T cells, regulatory T cells, Tr1 cells, activated CD8 T cells, natural killer cells, dendritic cells, B cells, and exhausted effector T cells [17,18]. LAG3 has multiple biological functions, for example, it is known to negatively regulate the proliferation, activation, and effector functions of T cells [52,53].…”

Section: Discussionmentioning

confidence: 99%

“…The ESTIMATE algorithm has been used in studies on multiple cancers, which have shown the effectiveness of such big databased algorithms [15,16]. Due to the prognostic signi cance of the integrated immune in ltration score in breast cancer [17], gastric cancer [18], oral squamous cell carcinoma [19], and ovarian cancer [20], its value can be used as an additional indicator to TNM staging system for patient survival prediction. However, very few studies have reported integrated immune in ltration in lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Immune Score Closely Associated With Tumor Microenvironment as A Prognostic Factor in Lung Adenocarcinoma

Chen²,

Liu³

et al. 2020

Preprint

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Background: The tumor microenvironment plays a vital role in tumor biology and has recently attracted widespread attention. However, the prognostic significance of integrated immune scores in lung adenocarcinoma has not yet been identified. This study aimed to systematically estimate the association between immune scores and prognosis and develop a clinical nomogram to predict the survival of patients with lung adenocarcinoma. This study also systematically explored the underlying prognostic factors of the immune score in lung adenocarcinoma.Methods: Public datasets for lung adenocarcinoma was acquired from The Cancer Genome Atlas data portal. The immune score of each sample was calculated using the ESTIMATE algorithm. Univariate and multivariate Cox regression analyses identified several significant prognostic factors and further developed a prognostic nomogram. The C-index, calibration curve, and ROC curve were used to evaluate the predictive accuracy and discriminative ability of the resultant nomogram. Results: We found that patients with higher immune scores had a better prognosis (log rank test p = 0.0004). The nomogram that integrated the immune score could effectively stratify high-risk LUAD patients in terms of clinical response. Patients in the high-risk groups usually had a worse prognosis (log rank test p < 0.0001) and higher mortality. The mortality rate in high and low risk groups was 42.67% and 26.37%, respectively (p < 0.0001). In addition, correlation analysis showed that the immune score was significantly dependent on the mRNA expression of immunotherapy-associated biomarkers (PD-1, PD-L1, and LAG3) as well as on the presence of certain immune cell subtypes, but had no correlation with tumor mutation burden.Conclusion: The immune score is a prognostic factor in lung adenocarcinoma. The nomogram with an integrated immune score can effectively predict the survival of patients with lung adenocarcinoma. The mechanism by which the immune score estimates the prognosis of patients with lung adenocarcinoma is related to the tumor immune microenvironment.

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Prognostic potential of an immune score based on the density of CD8+ T cells, CD20+ B cells, and CD33+/p-STAT1+ double-positive cells and HMGB1 expression within cancer nests in stage IIIA gastric cancer patients

Cited by 13 publications

References 36 publications

Association between density of tumor-infiltrating lymphocytes and prognoses of patients with gastric cancer

Association between density of tumor-infiltrating lymphocytes and prognoses of patients with gastric cancer

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis and experimental validation

Immune Score Closely Associated With Tumor Microenvironment as A Prognostic Factor in Lung Adenocarcinoma

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