Background
Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance.
Methods
The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively.
Results
Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues.
Conclusions
In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes especially in low-grade patients. This study explored the relationship between expression of integrin β1 (ITGB1), β3 (ITGB3) in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results: Furthermore, the results demonstrated that TGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues.Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
BackgroundInfectious mononucleosis (IM) is an infectious clinical entity commonly seen in adolescence and early adulthood. It is caused in the majority of cases by Epstein-Barr virus (EBV) and it presents as pharyngitis, fever, and lymphadenopathy. As the viruses mainly target the lymphocytes and reticuloendothelial system of the body, leading to the proliferation of the lymphatic tissues, it is often mistaken as lymphoma. Most cases of IM can be easily distinguished from lymphoma by clinical presentations and laboratory findings. However, atypical clinical presentations or laboratory findings occasionally occur, including the ages of patients over 30, generalized or isolated lymphadenopathy at unusual sites, negative heterophile antibody tests, absence of atypical lymphocytosis in the peripheral blood smear, etc. These atypical cases may lead to confused diagnosis. Therefore, IM should be differentiated from malignant lymphoma. In this paper, we reported a case of atypical IM in the cervical region of an adult, with elder age and longer disease course than typical IM.Case presentationIn this paper, we reported a case of IM in the cervical region of a 31-year-old man, and reviewed the recent literatures on the pathogenesis, as well as differential diagnosis of IM.ConclusionWhen facing enlarged tonsil or cervical lymph nodes, the pathologists should increase vigilance to the differential diagnosis between infectious diseases and lymphomas. Especially in ambiguous cases, it is essential to test for EBER by in situ hybridization to rule out IM before making a preliminary diagnosis of lymphoma.
Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between expression of ITGB1, ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results: Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
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