Significance of changes in the concentration of inflammatory factors in blood or cerebrospinal fluid in evaluating the severity and prognosis of spontaneous cerebral hemorrhage: A systematic review and meta-analysis

Association of inflammatory cytokines expression in cerebrospinal fluid with the severity and prognosis of spontaneous intracerebral hemorrhage

“…Additionally, a discernible linkage was observed between the admission GCS score and the concentrations of TNF-α and IL-8. In a similar vein, Yan et al [39] elucidated that the levels of TNF-α, IL-6, and IL-1β in the blood or CSF of individuals with acute spontaneous ICH were substantially elevated when juxtaposed with those of patients with mild ICH or healthy counterparts. Conversely, Belarbi et al [40] indicated that augmented levels of IL-11, TNF-α, and vascular endothelial growth factor were congruent with elevated neurologic de cit scores, suggestive of profound neurologic damage.…”

“…The nexus between neuroin ammatory response and prognosis subsequent to ICH remains somewhat ambiguous. While a pair of investigations focused on spontaneous intraventricular hemorrhage found no discernible correlation between the aseptic in ammatory response in the CSF and unfavorable prognosis [17,18], another inquiry [39] highlighted that ICH patients exhibiting elevated concentrations of TNF-α in the blood or CSF had a 1.06-fold increased likelihood of an adverse outcome, compared to their counterparts with reduced TNF-α levels. Furthermore, patients with augmented IL-6 concentrations had a predilection towards unfavorable outcomes, amplifying their odds by a factor of 61.6 compared to those with diminished IL-6 concentrations.…”

Association of inflammatory cytokines expression in cerebrospinal fluid with the severity and prognosis of spontaneous intracerebral hemorrhage

“…Furthermore, a clear link was observed between the admission GCS score and the levels of TNF-α and IL-8. In a similar context, Yan et al [ 39 ] found that levels of TNF-α, IL-6, and IL-1β in the blood or CSF of patients with acute spontaneous ICH were significantly higher compared to patients with mild ICH or healthy individuals. Additionally, Belarbi et al [ 40 ] noted that increased levels of IL-11, TNF-α, and vascular endothelial growth factor correlated with higher neurologic deficit scores, indicating more severe neurological damage.…”

“…The relationship between the neuroinflammatory response and prognosis following ICH remains somewhat unclear. While some studies on spontaneous intraventricular hemorrhage reported no significant link between aseptic inflammation in the CSF and poor prognosis [ 17 , 18 ], another study [ 39 ] indicated that ICH patients with elevated levels of TNF-α in blood or CSF had a slightly increased risk of adverse outcomes. This study also found that patients with higher IL-6 levels were much more likely to experience unfavorable outcomes, suggesting the importance of measuring TNF-α and IL-6 in prognostic assessments for ICH patients.…”