The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)

Abstract

Background Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. Conclusions In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.

Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets

“…MarvelD1 in glial cells inhibited the ITGB1 expression and phosphorylation of FAK Tyr397, which may lead to neurodegeneration and behavioral abnormalities in adult mice [34]. The clinical progression of intracerebral hemorrhage (ICH) is also associated with the expression of ITGB1 [35]; ITGB1 Fig. 2 ITGB1 and physiological function, benign disease.…”