Wound repair in horse limbs is often complicated by the development of exuberant granulation tissue (EGT) and excessive scarring while body wounds tend to repair uneventfully. EGT resembles the human keloid. While the events leading to keloid formation are not fully elucidated, tissue hypoxia has been proposed as a major contributing factor. The objective of this study was to investigate tissue oxygen saturation in healing full-thickness wounds created on the horse limb and body, using near-infrared spectroscopy. Spectroscopic reflectance data were collected from both anatomic sites at specific times following wounding. The oxygen saturation values of limb wounds were significantly inferior to those of body wounds during the early period of healing, indicating a temporary, relative state of hypoxia in the former during the inflammatory phase of repair. Horses present a weak, persistent inflammatory response to wounding, especially at the limb level. The relative hypoxia present acutely in limb wounds of horses may promote a feeble yet prolonged inflammatory response, which could interfere with and retard the subsequent phases of healing. Ongoing low-grade inflammation in horse wounds is accompanied by up-regulation of various inflammatory and profibrotic mediators, which might ultimately promote the development of fibroproliferative disorders such as EGT.

PS performed in skeletally immature dogs with hip dysplasia may provide an effect similar to a triple pelvic osteotomy and warrants further investigation.

Accessible summary Nobody knows how many people with learning difficulties get into trouble with the police. This article is about a project called No One Knows. It is finding out what happens when people with learning difficulties get into trouble with the police. Sometimes when people with learning difficulties get into trouble with the police they have to go to court. Sometimes they are sent to prison or have to visit a probation officer. Young people with a learning difficulty might have to go to a youth offending team. Some people with learning difficulties find it hard to understand what is happening. This can be upsetting. When people talk about the police, courts, prison, probation and youth offending they call it the criminal justice system. People who work in the criminal justice system do not always know how to support people with a learning difficulty. We want to know what people with a learning difficulty think about this. We want to know what people who work in the criminal justice system think as well. At the end of the project we will write a report about what people have told us. The report will tell the government what they should do to make things better for people with learning difficulties when they get into trouble with the police. Summary The prevalence of offenders with learning difficulties and learning disabilities is not agreed upon. What is clear, however, is that, regardless of actual numbers, many offenders have learning difficulties that reduce their ability to cope within the criminal justice system, for example, not understanding fully what is happening to them in court or being unable to access various aspects of the prison regime, including some offending behaviour programmes. Offenders with learning difficulties are not routinely identified and, as a result, often do not receive the support they need. No One Knows is a UK wide programme led by the Prison Reform Trust that aims to effect change by exploring and publicizing the experiences of people with learning difficulties who come into contact with the criminal justice system. The article highlights the aims of No One Knows and describes what, for the purpose of the programme, we mean by ‘learning difficulties and learning disabilities’. Problems in identifying precise numbers of offenders with learning difficulties and learning disabilities are discussed and attention drawn to recent research on prevalence. The context and some of the challenges of ‘prison life’ are identified and a number of early research findings from No One Knows are presented.

The clinical, radiographic and post-mortem findings in 6 horses with cryptococcal pneumonia and one horse with an abdominal cryptococcal granuloma are described. In pulmonary cryptococcosis, the lesions were either diffuse and multiple, with bilateral lung involvement, or localised mainly to the dorsocaudal region of one lung. The cases of diffuse multiple cryptococcosis were thought to be associated with haematogenous spread of the fungus after gastrointestinal infection and dissemination from regional lymph nodes. The localised form of the disease was thought to have been associated with inhalation of cryptococci. In all cases of pulmonary cryptococcosis, encapsulated yeast-like organisms were demonstrated in Wright's-stained sediment of tracheal washes. In the horse with the abdominal granuloma, cryptococci were present in a fine needle aspirate sample. Isolates of Cryptococcus neoformans var gattii were recovered from 2 of the 5 horses in which cultures were attempted. In addition to a history of previous illness that may have predisposed to infection, most horses in this report had been in areas in which Eucalyptus camaldulensis, or the closely related E rudis, were growing. In humans, an epidemiological relationship between E camaldulensis and infection with C neoformans var gattii has been suggested. Cases of equine cryptococcosis carry a poor prognosis and treatment was not attempted in any of these cases.

The overall performance of the IR-based test was similar to that of the colorimetric assay and was superior and more economic than other available tests.

Simple SummaryResearch on the transportation of horses has largely focused on the movement of horses by commercial livestock carriers. Information on factors associated with horse injuries sustained during private (non-commercial) transportation in small horse trucks and trailers is limited. This study surveyed drivers transporting their horses to equestrian events in southeastern Australia. Information on drivers, travel practice, vehicle characteristics and horse injury was collected. A total of 55/223 (24.7%) participants reported transportation related injuries to their horses. Of these 72% were described as horse associated (scrambling, slipping and horse-horse interaction), 11% due to mechanical failure, and 6% due to driver error. The risk of horse injury was not associated with driver age or gender, or experience. Drivers that answer the telephone whilst transporting horses, were more likely to report a previous injury experience. There was a trend for participants with <8 hours sleep prior to the survey to have previously had a horse injured. There was a modest positive association between increasing trailer age and the number of injuries. The range of trailer models prevented identification of the importance of individual design features. The study highlights the potential for horses to sustain transportation injuries in privately owned vehicles and warrants further study to address this risk to their welfare.AbstractEquine transportation research has largely focused on the commercial land movement of horses. Data on the incidence and factors associated with horse injuries during non-commercial transportation (privately owned horse trucks and trailers) is scant. This study surveyed 223 drivers transporting horses to 12 equestrian events in southeastern Australia. Data collected encompassed driver demographics, travel practice, vehicle characteristics, and incidents involving horse injury. Approximately 25% (55/223) of participants reported that their horses were injured during transportation. Of these 72% were owner classified as horse associated (scrambling, slipping and horse-horse interaction), 11% due to mechanical failure, and 6% due to driver error. Horse injury was not significantly associated with driver age, gender, or experience. Participants that answer the telephone whilst driving were more likely to have previously had a horse injured (p = 0.04). There was a trend for participants with <8 hours sleep prior to the survey to have experienced a previous transportation-related injury (p = 0.056). Increased trailer age was associated with a greater number of injury reports (r² = 0.20; p < 0.04). The diversity in trailer models prevented identification of the importance of individual design features. This study highlights the potential for horses to sustain transportation injuries in privately owned vehicles and warrants further study to address this risk to their welfare.

CWT varied with anatomic location and throughout healing. CWT of wounds developing EGT was significantly less than that of wounds without EGT.

The infrared spectroscopic patterns of fluid from joints with traumatic arthritis differed significantly from the corresponding patterns for controls. These alterations in absorption patterns may be used via an appropriate classification algorithm to differentiate the spectra of affected joints from those of controls.