Background: The wet-wrap dressing technique has proved to be beneficial in cases of exacerbated atopic dermatitis (AD) skin lesions. Objective: The effect of wet-wrap dressings was investigated in a controlled trial comparing a steroid (mometasone furoate 0.1%)-containing and a steroid-free (vehicle) preparation in an in-patient comparison study. Methods: 20 children aged 2–17 years with exacerbated AD were treated twice daily with wet-wrap dressings over a 5-day period. Results: AD in treated areas significantly improved in both study arms; however, the effect was significantly better in the mometasone-treated group (p < 0.01). Transepidermal water loss improved in both arms without any significant differences. Staphylococcus aureus colonization decreased during the first 3 days of active treatment independently of the therapeutic modalities chosen. At day 5, colony counts further dropped on the steroid-treated lesions. Conclusion: Application of the wet-wrap dressing technique for exacerbated AD lesions is effective, combination with a topical steroid being superior to a steroid-free application without bearing the risk of a bacterial superinfection.
Cetuximab belongs to a newly developed group of anti-cancer drugs, which have an inhibitory effect on the epidermal growth factor receptor (EGF-R). EGF-R plays a major role in the homeostasis of the epidermis and epidermal appendages. In addition, EGF-R is expressed on a variety of carcinomas of different origin and is thought to be partly associated with tumor progression. For this reason, inhibition of EGF-R seems a promising anti-cancer therapy, as shown in a few clinical trials. As a side effect of the therapy, a follicular rash often develops in the seborrheic areas; this cutaneous reaction is associated with longer survival. We present a typical case and discuss the important features of the follicular rash occurring after EGF-R inhibition.
Zusammenfassung
Tinea capitis‐ und Tinea corporis‐Erkrankungen Erwachsener sind insbesondere unter Bedingungen der Immunsuppression möglich. Eine umgehende native und kulturelle Untersuchung auf Pilzorganismen ist bei entsprechendem klinischen Verdacht zu veranlassen. Eine adäquate Behandlung sollte ohne Verzögerung begonnen werden. Bei nachgewiesener Tinea capitis muss eine systemische Therapie eingeleitet werden. Hierdurch können Verläufe mit entstellendem Haarverlust, bleibender Vernarbung der Kopfhaut, Dissemination der Erreger auf andere Hautareale sowie Infektion Dritter verhindert werden.
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