Follikuläre Arzneimittelreaktion auf Cetuximab

Braun‐Falco, Markus; Holtmann, Christiane; Lordick, Florian; Ring, Johannes

doi:10.1007/s00105-005-0979-5

Cited by 12 publications

(1 citation statement)

References 13 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, prevention of tumor progression is one of the primary goals of cancer prevention and control. However, agents that are currently being used for cancer therapy are generally cytotoxic, with serious side effects that can diminish the quality of life of cancer patients [ 6 ]. Recently, many efforts have been made to find non- or low-cytotoxic bioactive compounds that are present in the diet and that have potential anticancer effects [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Sophorae Radix on Human Gastric and Colorectal Adenocarcinoma Cells -Sophorae Radix and Cancer Cells-

Kim¹,

Lee²,

Kim³

et al. 2012

Journal of Pharmacopuncture

View full text Add to dashboard Cite

The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix (SR) and doxorubicin (DOX) in human gastric and colorectal adenocarcinoma cells. We used the human gastric and colorectal adenocarcinoma cell lines (MKN-45 and WIDR cells, respectively). We examined cell death by using the MTT(3-[4, 5-dimethylthiazol-2-yl]-2, 5- diphenyltetrazolium bromide) assay and the caspase 3 assay with SR. To examine the inhibitory effects of SR, we performed a cell cycle (sub G1) analysis for the MKN-45 and WIDR cells after three days with SR. The reversibility of SR was examined for one-day to five-day treatments with SR. SR inhibited the growth of MKN-45 and WIDR cells in a dosedependent manner. Also, we showed that SR induced apoptosis in MKN-45 and WIDR cells by using the MTT assay, the caspase 3 assay and the sub-G1 analysis. SR combined with DOX markedly inhibited the growth of MKN-45 and WIDR cells compared to SR or DOX alone. After 3 days of treating MKN-45 and WIDR cells with SR, the fraction of cells in the sub-G1 phase was much higher than that of the control group. Our findings provide insights into unraveling the effects of SR on human gastric and colorectal adenocarcinoma cells and into developing therapeutic agents for use against gastric and colorectal adenocarcinomas.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Sophorae Radix on Human Gastric and Colorectal Adenocarcinoma Cells -Sophorae Radix and Cancer Cells-

Kim¹,

Lee²,

Kim³

et al. 2012

Journal of Pharmacopuncture

View full text Add to dashboard Cite

show abstract

Current awareness: Pharmacoepidemiology and drug safety

2007

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

show abstract

Kutane Nebenwirkungen einer EGF-Rezeptor-Blockade und deren Management

et al. 2006

View full text Add to dashboard Cite

The receptor of the epidermal growth factor (EGF-receptor) plays a role in the pathogenesis of many human carcinomas. Recent strategies in anti-tumor therapy target the EGF-receptor, e.g., by the EGF-receptor blocking monoclonal antibody cetuximab or by small molecules inhibiting the tyrosine kinase activity of the EGF-receptor, such as gefitinib and erlotinib. The EGF-receptor is also expressed in normal human skin; in clinical trials with different EGF-receptor inhibitors, cutaneous side effects were common. We report on cutaneous side effects of EGF-receptor blockade, in particular acneiform lesions, xerosis and paronychia, and discuss their management.

show abstract

Follikuläre Arzneimittelreaktion auf Cetuximab

Cited by 12 publications

References 13 publications

Effects of Sophorae Radix on Human Gastric and Colorectal Adenocarcinoma Cells -Sophorae Radix and Cancer Cells-

Effects of Sophorae Radix on Human Gastric and Colorectal Adenocarcinoma Cells -Sophorae Radix and Cancer Cells-

Current awareness: Pharmacoepidemiology and drug safety

Kutane Nebenwirkungen einer EGF-Rezeptor-Blockade und deren Management

Contact Info

Product

Resources

About