In a retrospective study of 408 patients with Peyronie's disease 8 (1.9%) patients gave a positive family history for the condition. Sixty-three (15.4%) patients had a Dupuytren's contracture and trauma was considered to be an aetiological factor in 88 (21.5%) patients. One hundred and twenty-two (29.9%) patients had evidence of atherosclerosis and this is thought to be a factor in the pathogenesis of the disease. Peyronie's disease is not a single disease entity and is associated with many aetiological factors.
In a review of 1057 consecutive prostatectomies of which 95% were performed transurethrally, carcinoma was present in 11.8%. There were 10 deaths within a month of operation (0.9%), 9 of these patients having been exceptionally old and unfit. The rate of complications and the end results appear to justify using transurethral resection as the method of choice for prostatectomy whenever it is feasible.
Abstract. We propose a compositional specification theory for reasoning about components that interact by synchronisation of input and output (I/O) actions, in which the specification of a component constrains the temporal ordering of interactions with the environment. Such a theory is motivated by the need to support composability of components, in addition to modelling environmental assumptions, and reasoning about run-time behaviour. Models can be specified operationally by means of I/O labelled transition systems augmented by an inconsistency predicate on states, or in a purely declarative manner by means of traces.We introduce a refinement preorder that supports safe-substitutivity of components. Our specification theory includes the operations of parallel composition for composing components at run-time, logical conjunction for independent development, and quotient for incremental development. We prove congruence properties of the operations and show correspondence between the operational and declarative frameworks.
This study concerns 2043 male partners of infertile marriages who underwent testicular biopsy in the 28 years from 1955 to 1982. In a review of the pathological material carcinoma in situ (CIS) was diagnosed in 8 men (0.39%). Six of these men were later found to have invasive germ cell tumours; one has remained tumour-free and one is lost to follow-up. The implication of these findings in relation to the selection of patients for biopsy and the treatment of CIS when diagnosed is discussed.
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