Aim This study set out to gain insight into views held by children's nursing students, lecturers and clinically based nurse mentors about interprofessional education (IPE).Method A qualitative research design was undertaken. Small focus groups were held with pre-registration children's nursing students, and semi-structured interviews with university lecturers and clinically based nurse mentors to find out information about their understanding of IPE.Findings Participants not only valued IPE, but they agreed that it had the potential to positively affect the care of children, young people and their families.Conclusion It is important that professionals collaborate to ensure students receive high quality IPE learning experiences.
Preceptorship was first promoted as part of the Project 2000 reforms, and evidence suggests it remains valuable to newly qualified nurses. Although there is a lack of research of its effect on patient care, what research there is highlights various positive aspects of preceptorship programmes for newly qualified nurses, preceptors, and organisations. This article summarises the results of a scoping review of the literature, published since 2009, on preceptorship. It also describes a preceptorship initiative in London led by Health Education England.
The administration of traditional NSAIDs is associated with a three-fold increase in the risk of development of signi®cant gastrointestinal complications, depending on previous risk factors. 1±3 Cross-sectional studies indicate that gastric or duodenal ulcers are present in 10±25% of patients on long-term NSAIDs.2, 4, 5 Most NSAIDinduced ulcers heal spontaneously without treatment, with or without discontinuation of NSAID therapy. 6 However, a small proportion of the ulcers produced by NSAIDs progress to clinically serious events, such as a perforation or a bleeding ulcer. 2,7 The critical factors in the pathogenesis of these serious events are unknown, but the particular type and dose of NSAID taken, the location of the ulcer in relation to vessels and the effect of NSAIDs on platelet function may be important, as well as whether there is adequate healing of ulcers.
8±11One of the primary mechanisms responsible for the gastrointestinal toxicity produced by NSAIDs is believed to be suppression of endogenous gastric prostaglandin synthesis. Another is the`topical' effect, which may involve a surface membrane phospholipid interaction and/or an effect to uncouple mitochondrial oxidative phosphorylation.12±16 With the identi®cation 17 of two distinct isoforms of cyclooxygenase (COX) responsible for prostaglandin synthesis, COX-1 and COX-2, their roles in the pathogenesis of NSAID-induced gastroduodenal ulcers have been debated. In normal gastric tissue, high levels of COX-1 are expressed, whereas SUMMARY Background: Failure of ulcer healing may be critically important to the development of serious gastrointestinal complications in patients on long-term NSAIDs. Aim: To determine the effect of indometacin, celecoxib, a cyclooxygenase-2-speci®c inhibitor, and nabumetone, a pro-drug, on ulcer healing rates in the rat. Methods: Gastric ulcers were induced using a cryoprobe. An NSAID or a vehicle control was administered to groups of eight rats for 3 or 6 days (2 mg/kg indometacin, 9 mg/kg celecoxib or 40 mg/kg nabumetone). The ulcer area was measured and epithelial proliferation at the ulcer margins was measured histochemically. The effect of the drugs on intestinal prostaglandin levels was also assessed.
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