The evolution of agriculture towards intensive farming leads to an increasing demand for animal identification associated with high traceability, driven by the need for quality control and welfare management in agricultural animals. Automatic identification of individual animals is an important step to achieve individualised care in terms of disease detection and control, and improvement of the food quality. For example, as feeding patterns can differ amongst pigs in the same pen, even in homogenous groups, automatic registration shows the most potential when applied to an individual pig.
In patients with castration-resistant prostate cancer (CRPC), clinical resistances such as androgen receptor (AR) mutation, AR overexpression, and AR splice variants (ARVs) limit the effectiveness of second-generation antiandrogens (SGAs). Several strategies have been implemented to develop novel antiandrogens to circumvent the occurring resistance. Here, we found and identified a bifunctional small molecule Z15, which is both an effective AR antagonist and a selective AR degrader. Z15 could directly interact with the ligand-binding domain (LBD) and activation function-1 region of AR, and promote AR degradation through the proteasome pathway. In vitro and in vivo studies showed that Z15 efficiently suppressed AR, AR mutants and ARVs transcription activity, downregulated mRNA and protein levels of AR downstream target genes, thereby overcoming AR LBD mutations, AR amplification, and ARVs-induced SGAs resistance in CRPC. In conclusion, our data illustrate the synergistic importance of AR antagonism and degradation in advanced prostate cancer treatment.
China's first Mars exploration mission (Tianwen‐1), launched on July 23, 2020 with the goal of “orbiting, landing, and roving,” and its tentative landing areas (TLAs) are Chryse Planitia (TLA 1) and Isidis‐Elysium Planitia (TLA 2). Dust storm is a typical activity on Mars; it has strong interaction with atmospheric circulation and will influence the visibility of the Martian surface. To ensure the safety and accuracy for landing, it is meaningful to analyze the probability of dust storm activity during Entry‐Descent‐Landing (EDL) season in TLAs. First, based on Mars Orbiter Camera (MOC) and Mars Color Imager (MARCI) Daily Global Maps (MDGMs) from Mars Years 24–31, we identified 882 dust storms within the 2,000 km radius monitor circle of TLA 2 (short for TLA 2‐C). Second, the average daily probability of dust storm activity (Adp_ds) in TLA 2‐C was calculated, with a range of 0% to 14.13% showing obvious seasonality and discontinuity. Third, we divided TLA 2‐C into 0.5° longitude × 0.5° latitude square grids and calculated their spatial probability of dust storm activity. The spatial probability of dust storm in TLA 2‐C ranged from 0% to 11.87% and generally reduced from north to south. Finally, according to the temporal and spatial dust storm probability in TLA 2 during EDL season, we suggested the optimal landing time of China's Tianwen‐1 mission was in Ls = 20–41° and selected five preferred landing areas with the spatial probability of dust storm <3% for this mission.
The first Mars exploration mission from China (Tianwen-1) was launched on 23 July 2020 with the goal of “orbiting, landing, and roving”. The occurrence of dust storm activities is an important criterion of assessing atmospheric risk for the Tianwen-1 landing process. Dust storm activities from Mars Year (MY) 24 to MY32 in southern Utopia Planitia were identified. Most dust storms only appeared in one Mars Daily Global Map (MDGM), with a lifetime of less than or equal to solar longitude (Ls) = 0.5°. Only if the lifetime of a dust storm is greater than or equal to Ls = 1° can it reach the primary landing ellipse. From Ls = 0–50°, dust storms are mostly in the diffusion stage with a maximum speed of movement of 2479 km/Ls. Then, the speed gradually decreases to the minimum value of 368 km/Ls when the dust storm is in the dissipation stage. If a dust storm moves at an average speed of 750 km/Ls, the safe landing zone is a circle within a radius of 750 km centered on the primary landing ellipse. From March to May 2021, eight dust storms were identified in the Moderate Resolution Imaging Camera (MoRIC) mosaics. Because there was no dust storm activity in MoRIC mosaic on 13 May 2021, we concluded that there would be no dust storm in the primary landing ellipse on 15 May (MY36, Ls = 45.1°). Therefore, the landing time of the Tianwen-1 probe was finally determined as 15 May, which successfully landed in the south of the Utopia Planitia, and the in-situ investigation was carried out by the Zhurong Mars rover.
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