Design, synthesis, and biological evaluation of (E)-N′-substitute-4-((4-pyridylpyrimidin-2-yl)amino)benzohydrazide derivatives as novel potential CDK9 inhibitors

He, Fengming; Wang, Cong; Cao, Yin; Li, Chenfan; Zhao, Shengxian; Wu, Zhen; Hu, Hongyu; Fang, Meijuan

doi:10.1016/j.arabjc.2022.104039

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Again, we refluxed with compounds such as 2, 3, and 4-pyridyl-propenone. The resulting products reacted with hydrazine to form the reported products, which, followed by a condensation reaction with suitable aldehydes, gave hydrazone products [85]. Carboxamide and carbothioamide derivatives were yielded by first refluxing p-aminobenzoate with cyan-amide in the presence of conc.…”

Section: Synthesis Of Anticancer Agentsmentioning

confidence: 99%

“…Reasonable activity was exhibited by compound Benzo[d]thiazolyl)methoxyphenyl-triazolyl methyl aniline against cancer cell lines with GI 50 ranges from 0.55 to 1.2 µM [84]. Evaluation of synthetic compounds as CDK9 inhibitors exhibited exceptional antiproliferative activities of the compound amino-benzohydrazide against cancer cells with IC 50 values ranging between 0.57 ± 0.02 µM and 1.73 ± 0.09 µM [85]. Among all of the synthesized structures, excellent antagonist activity was shown by compound Nbutyl-2-( 4-((4-(pyridin-4-yl)pyrimidin-2-yl)amino)benzoyl)hydrazine-1-carboxamide having EC 50 = 1.68 ± 0.22 µM.…”

Section: Anticancer Activitymentioning

confidence: 99%

“…Scheme 3. Synthetic routes of p-aminobenzoic acid derivatives having anticancer activities (adapted from ref [33,34,[83][84][85][86][87][89][90][91][92][93][95][96][97]101]…”

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confidence: 99%

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Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications

Haroon,

Farwa,

Arif

et al. 2023

Biomedicines

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A “building block” is a key component that plays a substantial and critical function in the pharmaceutical research and development industry. Given its structural versatility and ability to undergo substitutions at both the amino and carboxyl groups, para-aminobenzoic acid (PABA) is a commonly used building block in pharmaceuticals. Therefore, it is great for the development of a wide range of novel molecules with potential medical applications. Anticancer, anti-Alzheimer’s, antibacterial, antiviral, antioxidant, and anti-inflammatory properties have been observed in PABA compounds, suggesting their potential as therapeutic agents in future clinical trials. PABA-based therapeutic chemicals as molecular targets and their usage in biological processes are the primary focus of this review study. PABA’s unique features make it a strong candidate for inclusion in a massive chemical database of molecules having drug-like effects. Based on the current literature, further investigation is needed to evaluate the safety and efficacy of PABA derivatives in clinical investigations and better understand the specific mechanism of action revealed by these compounds.

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Section: Synthesis Of Anticancer Agentsmentioning

confidence: 99%

Section: Anticancer Activitymentioning

confidence: 99%