BackgroundOsteonecrosis of the femoral head (ONFH) is generally characterized as an irreversible disease and tends to cause permanent disability. Therefore, understanding the pathogenesis and molecular mechanisms of ONFH and developing effective therapeutic methods is critical for slowing the progress of the disease.Methodology/Principal FindingsIn this study, an experimental rabbit model of early stage traumatic ONFH was established, validated, and used for an evaluation of therapy. Computed tomography (CT) and magnetic resonance (MR) imaging confirmed that this model represents clinical Association Research Circulation Osseous (ARCO) phase I or II ONFH, which was also confirmed by the presence of significant tissue damage in osseous tissue and vasculature. Pathological examination detected obvious self-repair of bone tissue up to 2 weeks after trauma, as indicated by revascularization (marked by CD105) and expression of collagen type I (Col I), osteocalcin, and proliferating cell nuclear antigen. Transplantation of hepatocyte growth factor (HGF)-transgenic mesenchymal stem cells (MSCs) 1 week after trauma promoted recovery from ONFH, as evidenced by a reversed pattern of Col I expression compared with animals receiving no therapeutic treatment, as well as increased expression of vascular endothelial growth factor.Conclusions/SignificanceThese results indicate that the transplantation of HGF-transgenic MSCs is a promising method for the treatment for ONFH and suggest that appropriate interference therapy during the tissue self-repair stage contributes to the positive outcomes. This study also provides a model for the further study of the ONFH etiology and therapeutic interventions.
An analytical solution of an infinite lubricated inclined slider bearing with nonNewtonian Powell-Eyring fluid as lubricant is presented. The homotopy perturbation method (HPM) is used and solutions for velocity components and pressure distribution in the slider bearing are derived with the method. The pressure distributions in the bearing are illustrated graphically for a range of non-Newtonian fluid material and bearing geometric parameters, and the effects of these parameters on the load carrying capacity of the bearing are discussed.
This paper presents a numerical study of a uniform flow past a rectangular cylinder using the incompressible lattice Boltzmann method (ILBM). Firstly, we use the ILBM to simulate the flow past a square cylinder symmetrically placed in a two-dimensional channel and results are validated against the well-resolved results obtained using finite-difference method and finite-volume method. Secondly, the effects of the aspect ratio defined as R = width/height on the fluid forces, vortex shedding frequency and the flow structures in the wake are investigated. Aspect ratios ranging from 0.15 to 4.00 and four Reynolds numbers Re = 100, 150, 200 and 250 are selected for the investigation. The results show that the effects of aspect ratio on physical quantities such as drag and lift coefficients, Strouhal number and the vortex shedding mechanism are very notable in the range between 0 and 2. In general, the drag coefficient decreases with the aspect ratio and the decreasing rate is more distinct in the range of 0.15 ≤ R ≤ 2.0. There is no local maximum found at around R = 0.6 in the drag coefficient as reported for higher Reynolds numbers in the literature. However the root-mean-square value of the lift coefficient shows a maximum value at R ≈ 0.5 for all Reynolds numbers selected. The variation of Strouhal number with R appears to be different for four selected Reynolds numbers. Especially for Re = 250, a discontinuity in St, as has been observed for higher Reynolds numbers, is observed at around R = 1.45 where multiple peaks are found in the result of Fourier spectrum analysis of the lift force and irregular vortex shedding behavior with no fixed shedding frequency is observed from the instantaneous vorticity contours. Such discontinuity is not observed for Re = 100, 150 and 200. The present results using the LBM are compared with some existing experimental data and numerical studies. The comparison shows that the LBM can capture the characteristics of the bluff body flow well and is a useful tool for bluff body flow studies.
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