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Graphical abstract The effects of pyridoxine deficiency and benzene inhalation exposure (0 or 100 ppm) on hepatic CYP2E1 protein expression (A) and activity (B) in control (CD) and pyridoxine-deficient (PD) B6C3F1 mice. ( a, b Significantly different from CD-0 controls at a p < 0.05 and b p < 0.001 , respectively; c Significantly different from PD-0 controls at p < 0.05 ).