Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B6C3F1 mice

Abstract

Graphical abstract The effects of pyridoxine deficiency and benzene inhalation exposure (0 or 100 ppm) on hepatic CYP2E1 protein expression (A) and activity (B) in control (CD) and pyridoxine-deficient (PD) B6C3F1 mice. ( a, b Significantly different from CD-0 controls at a p < 0.05 and b p < 0.001 , respectively; c Significantly different from PD-0 controls at p < 0.05 ).