The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B₆C₃F₁mice

Characterization of mitochondrial ferritin‐deficient mice

“…2A–2G). Similar to observations made in C57BL/6J x C3H (B6C3F1) mice maintained on a pyridoxine-deficient diet(17), we noted a decreased MCV and hematocrit, along with decreased MCH, reticulocyte counts and CHR. The lack of decrease in HGB levels in our mice, while noted in the study in B6C3F1 mice, may have been due to strain-specific differences.…”

The long-term effect of a protein-deficient-diet enriched with vitamin B6 on the blood parameters in unexercised and exercised rats

“…Pyridoxine is involved in the proper functioning of the haematological system. Vitamin B6 deficiency significantly reduced MCV, hemoglobin and haematocrit in mice; however, the addition of pyridoxine for 3 days increased HGB levels and HCT, MCV and MCH parameters (Tangjarukij, Navasumrit, Zelikoff, & Ruchirawat, 2009). In our study, the addition of vitamin B6 caused a significant increase in the number of red blood cells and the percentage of haematocrit (in comparison to the control and to the proteindeficient groups) and hemoglobin content (when compared to the protein-deficient group).…”

Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise

“…Vitamin B 6 is involved in proper functioning of the haematological system. Vitamin B 6 deficiency caused a reduction of the mean corpuscular volume (MCV), haemoglobin, and haematocrit (HCT) in mouse blood; the parameters were restored after three days of vitamin B 6 supplementation [35]. We showed here that the addition of vitamin B 6 to the protein-deficient diet improved the haemoglobin concentration in both exercised and unexercised rats, but it did not affect HCT and MCV parameters.…”