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Piperine, one of the main components of Piper longum Linn. and P. nigrum Linn., is a plant alkaloid with a long history of medicinal use. Piperine has been shown to modulate the immune response, but the mechanism underlying this modulation remains unknown. Here, we examined the effects of piperine on lipopolysaccharide (LPS)-induced inflammatory responses in bone-marrow-derived dendritic cells (BMDCs). Piperine significantly inhibited the expression of major histocompatibility complex class II, CD40 and CD86 in BMDCs in a dose-dependent manner. Furthermore, piperine treatment led to an increase in fluorescein-isothiocyanate-dextran uptake in LPS-treated dendritic cells and inhibited the production of tumour necrosis factor alpha and interleukin (IL)-12, but not IL-6. The inhibitory effects of piperine were mediated via suppression of extracellular signal-regulated kinases and c-Jun N-terminal kinases activation, but not p38 or nuclear factor-κB activation. These findings provide insight into the immunopharmacological role of piperine.

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Purpose – The purpose of this paper is to describe a compact wheelchair, which has two 3-degrees of freedom (DOF) legs and a 1-DOF base (the total DOF of the leg system is 7) for stair-climbing, and wheels for flat surface driving. Design/methodology/approach – The proposed wheelchair climbs stairs using the two 3-DOF legs with boomerang-shaped feet. The leg mechanisms are folded into the compact wheelchair body when the wheelchair moves over flat surfaces. The authors also propose a simple estimation method of stair shape using laser distance sensors, and a dual motor driving system to increase joint power. Findings – The proposed wheelchair can climb arbitrary height and width stairs by itself, even when they are slightly curved. During climbing, the trajectory of the seat position is linear to guarantee the comfort of rider, and the wheelchair always keeps a stable condition to ensure the stability in an emergency stop. Originality/value – The wheelchair mechanism with foldable legs and driving wheels enables smooth stair climbing, efficient flat surface driving and additional useful motions such as standing and tilting.

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