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Background: The molecular imprinting technique has been applied in many fields including separation, artificial antibody mimics, catalysis, sensing studies, and drug delivery. The reasons for the popularity of this technique among the researchers are high selectivity due to the cavities that are formed on the polymer surface for the specific analyte, high robustness, high durability under extreme conditions and low cost. When these advantages are combined with the advantages of electrochemical methods such as rapid response time, ease of use, cheapness and miniaturizability, Molecularly Imprinted Polymer (MIP) based electrochemical sensors turn out to be a widely-preferred sensing tool. Objective: This article provides the reader with information on MIP-based electrochemical sensors and reviews the applications of the MIP sensors prepared by electropolymerization of orthophenylenediamine, a monomer whose mechanical and chemical stability is very high. Results and Conclusion: The literature survey summarized in this review shows that cyclic voltammetry is the most widely preferred electrochemical technique for electropolymerization of o-PD. The media chosen is generally acetate or phosphate buffers with different pH values. Although there are numerous solvents used for template removal, generally methanol and NaOH have been chosen.

A new capillary electrophoresis method has been developed to analysis of paracetamol (PAR), caffeine (CAF) and codeine (COD) phosphate from pharmaceutical dosage forms. Good results were obtained by using a background electrolyte solution consist of 25 mM (pH 8.5) phosphate buffer solution containing 10% methanol. The separation was performed through an uncoated fused-silica capillaries (50 μm internal diameter, 56 cm total length, 47.5 cm effective length) at 25ºC with the application of 10 seconds of hydrodynamic injection at 40 mbar pressure and a potential of 27 kV. Detection wavelength was chosen 210 nm. Under optimum conditions, the migration times were found 4.427 min for PAR, 3.952 min for CAF, and 3.253 min for COD-phosphate. Linearity ranges were determined 99.72 -1994.40 μg mL -1 for PAR, 5.75 -115.04 μg mL -1 for CAF and 1.84 -36.80 μg mL -1 for COD-phosphate for the method. Limit of detections were found 0.724 μg mL -1 for PAR, 0.533 μg mL -1 for CAF and 0.263 μg mL -1 for COD-phosphate in this study. Also, limit of quantitations were found 2.415 μg mL -1 for PAR, 1.776 μg mL -1 for CAF and 0.877 μg mL -1 for COD-phosphate. According to the obtained results, the method is sensitive, specific and repeatable to analysis of PAR, CAF and COD-phosphate.

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