Polychlorinated biphenyls (Aroclor 1221, 1232, 1242, 1248, 1254, 1260, 1262, and 1268), polychlorinated terphenyls (Aroclor 5460), a mixture of polychlorinated biphenyls and terphenyls (Aroclor 4465) and polybrominated biphenyls (BP-6) were administered in a single dose, 100 mg/kg body weight injected orally, to mature male and female Japanese quail. Two hr after Aroclor treatment, pentobarbital sleeping times were prolonged (2 to 3 times control) in both male and female quail. Twenty-four hr after treatment, sleeping times were similar to those of controls. However, 48 hr after treatment with Aroclor 1248 through Arolcor 5460 and with BP-6, sleeping times of males were only 1/2 those of controls, whereas after treatment with Aroclor 1221, 1232 and 1242, sleeping times were similar to those of controls. The reduction in sleeping times of male quail 48 hr after administration of PCBs was correlated with the percentage of chlorine in the PCB with greater reductions in male than female quail. The response after three days ad libitum feeding of 300 ppm of each substance was the same as the response 48 hr after a single oral injection. Although very few birds died from the toxicity of the Aroclors and BP-6, mortality was greatly increased during anesthesia when the pentobarbital was administered two hr after single oral dosing.
The sequence of water and electrolyte events was followed during development of deciduoma in rats. Minutes after scratching the endometrium, Na and Cl increased and K decreased, probably due to the influx of blood. These changes were followed by a water imbibition at 24 and 48 hours and an increase in K. Damaged horns increased in weight and width during this period. Water and electrolyte alterations were similar in ovariectomized rats. ovariectomized rats given progesterone, and intact rats during the first 48 hours, suggesting that these initial effects were due to the inflammation resulting from the injury inflicted. During the next 48 hours injured uterine horns of ovariectomized rats regressed and composition approached that of uninjured tissue. In contrast, composition of injured horns of progesterone rats or rats with intact ovaries was markedly different from uninjured tissue. Decidual tissue H2O, K, Na and Cl were significantly higher than in undeveloped uterine horns. Ionic composition characteristic of decidual growth was remarkably similar to the ionic pattern exhibited during the inflammatory state.
Alterations in blood biochemical values of Yearling breeder toms following parenteral administration of cadmium (Cd) were well evaluated. Each treated member of a pair of (total 24 pairs) 0f toms received a single dose of 4.5mg of Cd per kg. body weight (0.04-mole). The birds were sacrificed at 0,6,24 and 192 hours : post-treatment. Highly significant (P<0.0001).increase in serum Cd concentration was observed in the Cd-injected toms, Reduction in the blood have been used to produce useful serum Cd (P<0.05) at the successive post-necropsy periods indicated systematic clearance of the metal from the fluid. Nearly 50 percent eliminated by 24 h post-treatment. Serum changes glutamic pyruvic transaminase (SGPT) was due to the similarly increased (P<0.05) in the Cd-treated birds and was presumed to have originated mainly from damaged skeletal muscle tissues. The cadmium treatment did not affect (P>0.05) serum testosterone level, total protein, total haemoglobin, lactate dehydrogenase, packed cell volume or serum glutamic oxaloacetic transaminase. It was concluded from these observations that the Cd treatment did not seem to have interfered seriously with renal or hepatic functions, iron, copper and zinc metabolism or caused significant damage to myocardial issue.
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