This method provides a stable and durable repair. The laparoscopic access reduces morbidity. The operation time for this procedure is approximately 50 min.

The results of this short-term follow-up study show that sports activity after total hip resurfacing surgery is still possible. Physical activity level increased with a shift toward low-impact sports. Duration of sports participation increased. High-impact sports activities decreased. These findings can be important for the decision-making process for hip surgery and should be communicated to the patient.

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Introduction: No validated questionnaire that evaluates vaginal symptoms is currently available in the German language. Here, we report the translation and validation process of the German ICIQ-VS. Subjects: Pilot study: 10 patients without any specific disease. Main study: 58 patients (cases) suffering from genital descensus higher than grade 1 pelvic organ prolapse quantification (POPQ) and 51 patients (controls) without vaginal affections. Methods: To establish a cultural-adaptive equivalent in German, recommendations from Guillemin et al. [J Clin Epidemiol 1993;46:1417–1432] were carefully followed. Participants of the main study were asked to fill in the questionnaire at three time points [baseline (T1), 7 days later (T2) and 1 year later (T3)]. Reliability, validity and sensitivity to change were evaluated. Results: In our pilot study, all questionnaire items were correctly interpreted and answered. In the main study, no changes from the original format were observed after translation and cultural adaptation. For the cases, internal consistency was acceptable (Cronbach’s alpha 0.72–0.79) and test-retest reliability was moderate to near-perfect for single items (weighted kappa 0.67–0.94). Sensitivity to change and content validity were excellent. Construct validity revealed statistically significant differences between groups. Conclusion: The ICIQ-VS has successfully been translated and validated into the German language.

Objective – Our autopsy studies show possible links between classical Alzheimer pathology and decreased expression of nicotinic acetylcholine receptors. For further elucidation we are now using in vitro models. We report preliminary evidence for the impact of β‐amyloid on nicotinic receptor expression in hippocampal dissociation culture. Methods – Cultures (E18 rats) were grown in a serum‐free medium and incubated at 8 days in vitro for 3 days with 1 µM Aβ1–42. Expression of α4, α7, and β2 nicotinic receptor subunit protein was assessed immunohistochemically and rated semiquantitatively. Results – Aβ1–42 incubation resulted in a massive reduction of α4 protein‐expressing neurons, this effect was less pronounced for the α7 and β2 subunit protein. Conclusion – These findings provide first evidence for a direct impact of classical Alzheimer pathology features on nicotinic receptor expression in vitro. Our model will be useful for testing the potential of drugs to stop or reverse these effects.

Fragestellung: Postoperatives Spotting tritt in bis zu 25 % nach suprazervikalen Hysterektomien auf und wird von den Patientinnen häufig als störend empfunden. In der vorliegenden Studie untersuchen wir, ob die Spottingrate durch ein konusförmiges endoskopisches Aushöhlen des Zervikalkanals mit nachfolgender Verödung des restlichen Zervikalkanals im Vergleich zum geraden Absetzen reduziert werden kann und welche Auswirkungen dies auf die Stumpfinfektrate hat. Material und Methode: In die Studie wurden insgesamt 260 Patientinnen, die sich im Zeitraum zwischen Januar 2006 und Juni 2009 einer LASH unterzogen haben, aufgenommen. Bis Juli 2007 wurde der Gebärmutterhals gerade abgesetzt und der verbleibende Zervikalkanal bipolar koaguliert (LASH). Seit Juli 2007 wurde der Gebärmutterhals konusförmig ausgehöhlt und der verbleibende Zervikalkanal koaguliert (eLASH). Alle Patientinnen wurden nach einem minimalen Follow-up von 6 Monaten schriftlich bez. Spottingrate, postoperativen Infektionen/Wiederaufnahmen und dem Rauchverhalten befragt. Ergebnisse: 70% der Patientinnen beantworteten den Fragebogen (n = 183). 88 Patientinnen der LASH-Gruppe und 85 Patientinnen der eLASH-Gruppe füllten den Fragebogen komplett aus. Neun Patientinnen füllten den Fragebogen inkomplett aus. Bei 21,6 % (19/88) der LASH-Gruppe und 5,9 % (5/85) der eLASH-Gruppe trat ein postoperatives Spotting auf (p = 0,004). Die Stumpfinfektrate betrug 6,8 % (6/88) in der LASH-Gruppe und 5,9 % (5/85) in der eLASH-Gruppe (p = 0,999). Raucherinnen waren tendenziell häufiger von Stumpfinfektionen betroffen (9,4 % [5/53] vs. 5 % [6/120], p = 0,315). Schlussfolgerung: Postoperatives Spotting kann zwar nicht komplett vermieden, aber durch ein konusförmiges Aushöhlen zumindest deutlich re

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