A transplantable reticulum cell sarcoma with leukemic manifestations can be transmitted from one hamster to another by means of a mosquito, Aëdes aegypti (L.). The transmission seems to be by a transfer of tumor cells, and not by passage of some other oncogenic agent.
A hamster reticulum cell sarcoma, TM, was transmitted through the mosquito Aëdes aegypti (L) by a transfer of tumor cells. Tumor cells of TM remained viable up to 8 hours after ingestion by the mosquito. Feeding on or off the tumor did not effect the rate of transmission which was 10% in one series of experiments and 5% in another. It was estimated that tumor cells were transmitted by one to 2% of the mosquitos. An attempt to transmit the Rauscher virus leukemia by Aëdes aegypti failed. There was no evidence of immunity to the Rauscher virus conferred by a subclinical infection. There was no evidence of multiplication in the mosquito of an agent from TM or of the Rauscher virus.
In the paper by S. D. Morrison C. Mackay, Eleanor Hurlbrink, Jane E. Wier, M. Susan Nick and Florence K. Millar in the Quarterly Journal of Experimental Physiology (1967) 52, 51–67 the third paragraph of the legend to figure 3 should read:—
The 100 per cent values are: 15 ml., 2000 mOsm./kg., 27·5 mOsm., 34 ml., 255 g. and 25 g. for the urine volume, osmolality, total osmotic load, water intake, body weight and food intake respectively.
Peptic fragment 505-582 of bovine serum albumin, the "Phe" fragment, has been found useful in several laboratories for studies of antigenic sites, ligand binding and metabolism. It contains the entire carboxyterminal loop, Loop 9, of the albumin molecule. We present an improved preparation of this peptide. Peptide 505-582 is obtained in about 9% yield, along with a similar yield of the closely associated peptide 505-573 arising from a second peptic cleavage. The unusual ultraviolet absorption spectrum of these peptides shows triple maxima near 259 nm reflective of the high phenylalanine content and the total absence of tyrosine and tryptophan.
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