A simple, efficient and green methodology for the C−S cross‐coupling reaction using Pd(L‐Pro)2 as a heterogeneous catalyst was developed involving aryl iodides, thiols, green‐solvent and a low catalytic loading of palladium prolinate. In addition, the catalyst turned out to be recyclable and the products were obtained in good to excellent yields.
Background:
Sulfur-containing compounds represent an important class of chemical compounds due
to their wide range of biological and pharmaceutical properties. Moreover, sulfur-containing compounds may be
applied in other fields, such as biological, organic, and materials chemistry. Several studies on the activities of
sulfur compounds have already proven their anti-inflammatory properties and use to treat diseases, such as
Alzheimer’s, Parkinson’s, and HIV. Moreover, examples of sulfur-containing compounds include dapsone,
quetiapine, penicillin, probucol, and nelfinavir, which are important drugs with known activities.
Objective:
This review will focus on the synthesis and application of some sulfur-containing compounds used to
treat several diseases, as well as promising new drug candidates.
Results:
Due to the variety of compounds containing C-S bonds, we have reviewed the different synthetic
routes used toward the synthesis of sulfur-containing drugs and other compounds.
[Ce(l-Pro)2]2 (Oxa) was used as a recyclable heterogeneous catalyst under mild conditions for the preparation of 2-aryl-2,3-dihydroquinazolin-4(1H)-one derivatives. The one-pot protocol proceeds in ethanol using anthranilamide with several aldehydes at 50–55 °C. The catalyst can be recycled and reused three cycles without significant loss of catalytic activity.
In this work, we present a novel, efficient and green methodology for the synthesis of thioethers by the C–S cross-coupling reaction with the assistance of [Ce(l-Pro)2]2Ox as a heterogeneous catalyst in good to excellent yields.
A simple and convenient route for the synthesis of thia‐Michael products was established using pyrazol‐5(4H)‐one with various thiophenols in the presence of [Zn(L‐Pro)2],an efficient catalyst under mild reaction conditions. The salient features of this methodology are good yields, eco‐friendly catalyst, low catalyst loading and faster reaction times.
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