[Zn(L‐Pro)₂] as a Simple and Efficient Catalyst: A Convenient Route for the Synthesis of Thia‐Michael Derivatives via Green Chemical Approach

Abstract

A simple and convenient route for the synthesis of thia‐Michael products was established using pyrazol‐5(4H)‐one with various thiophenols in the presence of [Zn(L‐Pro)2],an efficient catalyst under mild reaction conditions. The salient features of this methodology are good yields, eco‐friendly catalyst, low catalyst loading and faster reaction times.

Pyrrolidinium Acetate (PyrrIL) as a Green and Recyclable Catalyst: Synthesis of 2-Phenyl Benzimidazoles and 2-Phenyl Benzothiazoles under Solvent-Free Conditions at Room Temperature

“…The above-mentioned reports contain drawbacks, such as the use of hazardous reagents, solvents, expensive catalysts, prolonged reaction times, high temperatures, and harsh reaction conditions, as well as the formation of unwanted products. The methodologies employing green catalysts, such as non metal salts, heterogeneous recyclable catalysts, or ionic liquids, [44][45][46][47][48][49][50][51] and green solvents, or solvent-free or microwave or ultrasonic conditions [52][53][54] , are desirable to promote sustainable ecofriendly research. [55][56][57] In this regard, ionic liquids (ILs) have shown promising results in a variety of synthetic processes because of their great selectivity and catalytic efficiency.…”

XantPhos Pd-G3 as an Efficient Catalyst: Microwave-Assisted C–S Cross-Coupling Reaction in DMF

“…Recent developments include pyrazoles, 24 Kabachnik-Fields, 25 thio-Michael addition, 26 dihydroquinazolin-4(1H)-ones, 27 and N, S-acetals 28 synthesis using hybrid catalysts. We would like to develop a C-S and C-Se cross-coupling reaction using a low-cost, efficient, and stable XantPhos Pd-G3 (2.5 mol %), K2CO3 (2.0 eq) as a base, in DMF, under microwave irradiation at 80 o C, 200W (100 psi) for 20-45 min (Scheme 1).…”

Highly Efficient Zn(L‐Pro)2 Catalyst for the Synthesis of 2‐Phenyl Benzimidazoles and 2‐Phenyl Benzothiazoles via Aerobic Oxygenation

“…Due to the wide variety of applications, a mild and environmentally friendly one‐pot synthesis of 2‐substituted benzothiazoles and benzimidazoles is required. Recently, our group reported the synthesis of dihydroquinazolin‐4(1H)‐ones, [45] pyrazole synthesis, [46] thio‐Michael addition reaction, [47] N, S‐acetals, [48] and Kabachnik‐Fields [49] using hybrid catalysts that are recyclable and eco‐friendly. In continuation of our reports, we present a simple, stable, cheap and one‐pot approach for the synthesis of 2‐substituted benzothiazoles and benzimidazoles utilizing Zn( L ‐Pro) 2 as an efficient and appropriate catalyst in ethanol at room temperature for 4–30 min as shown in Scheme 1.…”