Objective: To test the hypothesis that substituting artificially sweetened beverages (ASB) for sugarsweetened beverages (SSB) decreases intrahepatocellular lipid concentrations (IHCL) in overweight subjects with high SSB consumption. Methods: About 31 healthy subjects with BMI greater than 25 kg/m 2 and a daily consumption of at least 660 ml SSB were randomized to a 12-week intervention in which they replaced SSBs with ASBs. Their IHCL (magnetic resonance spectroscopy), visceral adipose tissue volume (VAT; magnetic resonance imaging), food intake (2-day food records), and fasting blood concentrations of metabolic markers were measured after a 4-week run-in period and after a 12-week period with ASB or control (CTRL). Results: About 27 subjects completed the study. IHCL was reduced to 74% of the initial values with ASB (N 5 14; P < 0.05) but did not change with CTRL. The decrease in IHCL attained with ASB was more important in subjects with IHCL greater than 60 mmol/l than in subjects with low IHCL. ALT decreased significantly with SSB only in subjects with IHCL greater than 60 mmol/l. There was otherwise no significant effect of ASB on body weight, VAT, or metabolic markers. Conclusions: In subjects with overweight or obesity and a high SSB intake, replacing SSB with ASB decreased intrahepatic fat over a 12-week period.
Background: A high fructose diet causes hypertriglyceridemia and hepatic insulin resistance in humans, but it remains unknown whether refined sugars exert different effects than naturally occurring sugars present in honey. Aim: To assess the metabolic effects of replacing 25% total energy from starch with honey or a pure fructose:glucose mixture. Methods: Eight healthy male were studied while consuming a controlled weight-maintenance, low fructose diet (control, CTRL), or a isocaloric diet in which 25% complex carbohydrates were substituted with either honey (HON; fructose:glucose ratio ¼ 1.7) or fructose:glucose mixture (FG) for eight days. On day 7, participants ingested a breakfast at 7:30 am, and a lunch at 12:00 pm, both corresponding to their ongoing experimental diet. On day 8, they had an oral glucose tolerance test (OGT) with dual glucose isotopes (oral 13 C-, iv 6,6 2 H 2-glucose). Results: On day 7, their postprandial glucose and insulin concentrations were lower with HON and FG than with CTRL but their plasma triglyceride concentrations and net substrate oxidation showed no difference. On day 8, there was no significant difference in glucose tolerance or postprandial suppression of glucose production between HON, FG and CTRL. Conclusions: Consuming a diet containing 25% energy as honey or pure fructoseeglucose slightly decreases postprandial blood glucose, but does not significantly increase postprandial plasma triglyceride, nor impair hepatic insulin sensitivity compared to an isocaloric starch diet.
Objective: Addition of fructose to the diet of normal weight and overweight subjects can increase postprandial plasma triglyceride and uric acid concentration. We, therefore, assessed whether replacing sugar-sweetened beverages (SSB) with artificially-sweetened beverages (ASB) in the diet of overweight and obese subjects would decrease these parameters. Methods: Twenty-six participants of the REDUCS study, which assessed the effects of replacing SSB by ASB over 12 weeks on intra-hepatocellular lipid concentration, were included in this sub-analysis. All were studied after a four-week run-in period during which they consumed their usual diet and SSBs, and after a 12-week intervention in which they were randomly assigned to replace their SSBs with ASBs (ASB arm) or to continue their usual diet and SSBs (control arm, CTRL). At the end of run-in (week 4) and again at the end of intervention (week 16), they took part in an 8.5 h metabolic investigation during which their plasma glucose, insulin, glucagon, lactate, triglyceride (TG), non-esterified fatty acids (NEFA), and uric acid concentrations were measured over a 30 min fasting period (−30–0 min), then every 2 h over 480 min. with ingestion of standard breakfast at time 0 min and a standard lunch at time 240 min. Breakfast and lunch were consumed together with a 3.3 dL SSB at week 4 and with either an ASB (ASB arm) or a SSB (CTRL arm) at week 16. After analyzing the whole group, a secondary analysis was performed on 14 subjects with hepatic steatosis (seven randomized to ASB, seven to CTRL) and 12 subjects without hepatic steatosis (six randomized to ASB and six to CTRL). Results: Ingestion of meals increased plasma glucose, insulin, glucagon, lactate, and TG concentrations and decreased NEFA concentrations, but with no significant difference of integrated postprandial responses between week 4 and week 16 in both ASB and CTRL, except for a slightly decreased glucagon response in ASB. There was, however, no significant postprandial increase in uric acid concentration in both arms. In the secondary analysis, replacing SSBs with ASBs did not significantly change postprandial TG and uric acid concentrations irrespective of the presence or not of hepatic steatosis, Conclusions: In overweight, high SSB consumers, replacing SSBs with ASBs during 12 weeks did not significantly alter post-prandial TG and uric acid concentration, in spite of the lower energy and fructose content of the meals. These effects were globally the same in subjects without and with hepatic steatosis.
A high fructose diet can cause hypertriglyceridemia and hepatic insulin resistance. In this study, we assessed whether honey may have different metabolic effects than an isomolar glucose:fructose mixture due to its polyphenols and antioxidant content.Eight healthy male volunteers were studied in a randomized, crossover design after 7 days on a weight‐maintenance, low fructose diet (control, C), or on isocaloric diets in which 25% complex carbohydrates were substituted with either acacia honey (HON; fructose:glucose ratio = 1.7) or 15.7% fructose and 9.3% glucose (FG). During all three dietary conditions, a day‐long metabolic profile was obtained, and an oral glucose tolerance test (OGT) with dual glucose isotope (oral 13C‐ , iv 6,6 2H2 glucose) was performed.Fasting triglyceride concentrations were not different between all three conditions (C:1.08±0.25 mmol/L control; HON:1.06±0.26, FG: 0.97±0.24). Postprandial TG responses were higher with HON and FG than with C, but there was no difference between HON and FG. 2‐hour blood glucose concentration during OGT was C:4.1±0.3 mmol/L, HON: 4.6±0.4, and FG: 4.3±0.3 (NS). Suppression of hepatic glucose output after oral glucose was the same in all three conditions (C: ‐69.9±4.4%, HON: ‐72.5±4.1, FG: ‐65.8±5.9, NS).These results indicate that in young healthy male a) consumption of a weight‐maintenance diet containing 25% energy as honey or as a fructose‐glucose mixture slightly increases postprandial triglyceride, but does not alter glucose tolerance nor suppression of hepatic glucose production, and b) the metabolic effects induced by honey and glucose‐fructose are not significantly different.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.