Sugar‐ and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial

Campos, Vanessa; Despland, Camille; Brandejsky, Vaclav; Kreis, Roland; Schneiter, Philippe; Chioléro, Arnaud; Boesch, Chris; Tappy, Luc

doi:10.1002/oby.21310

Cited by 57 publications

(84 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This agrees with a recent report in adults, in which the replacement of sugar by artificially sweetened beverages induced a significant decrease in intrahepatic fat, with no changes in body weight or insulin resistance [38]. Our data difered from those of Lustig et al [20] who found weight loss and metabolic improvement with only 9 days of isocaloric substitution of fructose with starch.…”

Section: Discussionsupporting

confidence: 90%

Effect of Restriction of Foods with High Fructose Corn Syrup Content on Metabolic Indices and Fatty Liver in Obese Children

et al. 2017

View full text Add to dashboard Cite

Objective: We examined the effect of restriction of foods with high fructose content in obese school children. Methods: In a clinical study, we selected 54 obese children 6 to 11 years old with high fructose consumption (>70 g/day) in order indicate dietary fructose restriction (<20 g/day) for 6 weeks. Anthropometry, liver ultrasound as well as glucose, insulin, lipids, leptin, IGFBP1, and RBP4 serum levels were collected. Results: The group of children had 80% adherence and reported decreased fructose consumption (110 ± 38.6 to 11.4 ± 12.0 g/day) and also a significant decrease in caloric (2,384 ± 568 to 1,757 ± 387 kcal/day) and carbohydrate consumption (302 ± 80.4 to 203 ± 56.0 g/day). The severity of steatosis improved significantly after fructose restriction (p < 0.000001). However, no changes in BMI, systolic blood pressure, or diastolic blood pressure were found. Only triglyceride levels decreased (1.44 ± 0.43 to 1.31 ± 0.38 mmol/l), High-densitiy lipoprotein cholesterol showed a marginal increase (1.45 ± 0.19 to 1.56 ± 0.44 mmol/l). Insulin resistance and RBP4 did not change. Conclusions: In school children, the restriction of high fructose foods with a decrease of caloric and carbohydrate intake at 6 weeks did not induce weight loss; however, triglyceride levels and hepatic steatosis decreased. Differences with other studies in regard to weight loss may be explained by adaptive changes on metabolic expenditure.

show abstract

Section: Discussionsupporting

confidence: 90%

Effect of Restriction of Foods with High Fructose Corn Syrup Content on Metabolic Indices and Fatty Liver in Obese Children

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Replacing SSB with ASB was the sole intervention, and, although subjects were advised not to change their usual diet, food intake was otherwise left ad libitum. We have reported elsewhere that ASB significantly reduced IHCL compared to control [7]. There was, however, no significant change in body weight, nor on any of the other fasting metabolic parameters.…”

Section: Introductionmentioning

confidence: 63%

“…Total energy intake decreased by 28%, and total sugar intake by 68% between week 4 and week 16 in the ASB arm, but did not change in CTRL. The effects of intervention on the main study outcome, IHCL, has been reported for all 27 participants [7]. IHCL decreased significantly in the ASB arm, but not in the CTRL arm, while body weight (90.1 vs. 91.0 in CTRL, 93.9 vs. 92.5 in ASB) did not change significantly in either group.…”

Section: Resultsmentioning

confidence: 99%

“…IHCL decreased significantly in the ASB arm, but not in the CTRL arm, while body weight (90.1 vs. 91.0 in CTRL, 93.9 vs. 92.5 in ASB) did not change significantly in either group. There was also no statistically significant difference for total body fat mass, visceral fat volume, nor for all measured fasting metabolic substrate and hormone concentrations [7]. …”

Section: Resultsmentioning

confidence: 99%

“…Participants with hepatic steatosis had more cardio-metabolic risk factors, i.e., higher BMI, VAT, and Homeostasis Model Assessment of Insulin resistance (HOMA) index, plasma triglyceride and cholesterol concentrations, uric acid concentrations, and lower HDL-cholesterol concentrations. They also had larger decreases of IHCL with ASB [7]. …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial

et al. 2017

Self Cite

View full text Add to dashboard Cite

Objective: Addition of fructose to the diet of normal weight and overweight subjects can increase postprandial plasma triglyceride and uric acid concentration. We, therefore, assessed whether replacing sugar-sweetened beverages (SSB) with artificially-sweetened beverages (ASB) in the diet of overweight and obese subjects would decrease these parameters. Methods: Twenty-six participants of the REDUCS study, which assessed the effects of replacing SSB by ASB over 12 weeks on intra-hepatocellular lipid concentration, were included in this sub-analysis. All were studied after a four-week run-in period during which they consumed their usual diet and SSBs, and after a 12-week intervention in which they were randomly assigned to replace their SSBs with ASBs (ASB arm) or to continue their usual diet and SSBs (control arm, CTRL). At the end of run-in (week 4) and again at the end of intervention (week 16), they took part in an 8.5 h metabolic investigation during which their plasma glucose, insulin, glucagon, lactate, triglyceride (TG), non-esterified fatty acids (NEFA), and uric acid concentrations were measured over a 30 min fasting period (−30–0 min), then every 2 h over 480 min. with ingestion of standard breakfast at time 0 min and a standard lunch at time 240 min. Breakfast and lunch were consumed together with a 3.3 dL SSB at week 4 and with either an ASB (ASB arm) or a SSB (CTRL arm) at week 16. After analyzing the whole group, a secondary analysis was performed on 14 subjects with hepatic steatosis (seven randomized to ASB, seven to CTRL) and 12 subjects without hepatic steatosis (six randomized to ASB and six to CTRL). Results: Ingestion of meals increased plasma glucose, insulin, glucagon, lactate, and TG concentrations and decreased NEFA concentrations, but with no significant difference of integrated postprandial responses between week 4 and week 16 in both ASB and CTRL, except for a slightly decreased glucagon response in ASB. There was, however, no significant postprandial increase in uric acid concentration in both arms. In the secondary analysis, replacing SSBs with ASBs did not significantly change postprandial TG and uric acid concentrations irrespective of the presence or not of hepatic steatosis, Conclusions: In overweight, high SSB consumers, replacing SSBs with ASBs during 12 weeks did not significantly alter post-prandial TG and uric acid concentration, in spite of the lower energy and fructose content of the meals. These effects were globally the same in subjects without and with hepatic steatosis.

show abstract

Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk

et al. 2022

View full text Add to dashboard Cite

IMPORTANCE There are concerns that low-and no-calorie sweetened beverages (LNCSBs) do not have established benefits, with major dietary guidelines recommending the use of water and not LNCSBs to replace sugar-sweetened beverages (SSBs). Whether LNCSB as a substitute can yield similar improvements in cardiometabolic risk factors vs water in their intended substitution for SSBs is unclear. OBJECTIVETo assess the association of LNCSBs (using 3 prespecified substitutions of LNCSBs for SSBs, water for SSBs, and LNCSBs for water) with body weight and cardiometabolic risk factors in adults with and without diabetes. DATA SOURCES Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception through December 26, 2021. STUDY SELECTION Randomized clinical trials (RCTs) with at least 2 weeks of interventions comparing LNCSBs, SSBs, and/or water were included.DATA EXTRACTION AND SYNTHESIS Data were extracted and risk of bias was assessed by 2 independent reviewers. A network meta-analysis was performed with data expressed as mean difference (MD) or standardized mean difference (SMD) with 95% CIs. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) system was used to assess the certainty of the evidence. MAIN OUTCOMES AND MEASURESThe primary outcome was body weight. Secondary outcomes were other measures of adiposity, glycemic control, blood lipids, blood pressure, measures of nonalcoholic fatty liver disease, and uric acid. RESULTSA total of 17 RCTs with 24 trial comparisons were included, involving 1733 adults (mean [SD] age, 33.1 [6.6] years; 1341 women [77.4%]) with overweight or obesity who were at risk for or had diabetes. Overall, LNCSBs were a substitute for SSBs in 12 RCTs (n = 601 participants), water was a substitute for SSBs in 3 RCTs (n = 429), and LNCSBs were a substitute for water in 9 RCTs (n = 974). Substitution of LNCSBs for SSBs was associated with reduced body weight (MD, −1.06 kg; 95% CI, −1.71 to -0.41 kg), body mass index (MD, −0.32; 95% CI, −0.58 to -0.07), percentage of body fat (MD, −0.60%; 95% CI, −1.03% to -0.18%), and intrahepatocellular lipid (SMD, −0.42; 95% CI, −0.70 to -0.14). Substituting water for SSBs was not associated with any outcome. There was also no association found between substituting LNCSBs for water with any outcome except glycated (continued) Key Points Question Are low-and no-calorie sweetened beverages (LNCSBs) as the intended substitute for sugarsweetened beverages (SSBs) associated with improved body weight and cardiometabolic risk factors similar to water replacement? Findings In this systematic review and meta-analysis of 17 randomized clinical trials, LNCSBs as a substitute for SSBs were associated with reduced body weight, body mass index, percentage of body fat, and intrahepatocellular lipid, providing benefits that were similar to those of water, the standard-of-care substitution.Meaning The findings of this study suggest that over the moderate term, LNCSBs are a viable alternative to water as a replacemen...

show abstract

Sugar‐ and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial

Cited by 57 publications

References 20 publications

Effect of Restriction of Foods with High Fructose Corn Syrup Content on Metabolic Indices and Fatty Liver in Obese Children

Effect of Restriction of Foods with High Fructose Corn Syrup Content on Metabolic Indices and Fatty Liver in Obese Children

Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial

Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk

Contact Info

Product

Resources

About