Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. The prepared formulation was subjected to physical characterization and physical-chemistry assessment. The gel was prepared from carbopol and 5% of borneol. The prepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, and accelerated stability with freezing-thaw cycle. The borneol was successfully incorporated into the carbopol formulation. Borneol gel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showing statistical difference in pH value, conductivity, and viscosity before and after test. Furthermore, the formulation showed a good spreadability. Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermal treatment of skin diseases.
This study aimed to carry out an ethnobotanical survey of medicinal plants used by inhabitants of the Rodeadouro Island, Jatoba Island and Massangano Island, located in The Submedium São Francisco River Valley. Also phytochemicals and preliminary pharmacological tests were performed to species most cited by the community. Ethnobotanical data were collected through observation visits and semi-structured interviews with 12 key informants. We calculated the relative importance (RI), the percentage of agreement related to the main uses (cAMU) and use value (UV). The aerial parts of Rhaphiodon echinus (Ness & Mart.) Schauer were used to obtain the lyophilizate (LYO-Re), crude ethanol extract (CEE-Re) and their hexanic (HEX-Re), chloroform (CLO-Re) and ethyl acetate (EA-Re) fractions. The microdilution technique was used for determining Minimum inhibitory concentration (MIC) for selected microorganisms. Already the spasmolytic effect was evaluated in isolated uterus fragments of Wistar rats, pre contracted with KCl 60 mM. We found 34 species cited, belonging to 22 families. The most plants were grown by locals. There were 51 different diseases, but the main indication was infectious and parasitic diseases. The species R. echinus was the most reported and it was indicated for urinary tract infection and dysmenorrhea. The screening revealed a higher prevalence of flavonoids, tannins, lignans and saponins in LYO-Re and AE-Re. Already terpene compounds were more present in HEX-Re and CLO-Re. The RE-Re fraction stood out with strong effect against E. coli and S. aureus while CEE-Re has moderate effect against gram-negative bacteria. The evaluation of the spasmolytic activity showed that LYO-Re, CEE-Re and HEX-Re fractions have similar activity, with partial effect and concentration-dependent response. This work brought about knowledge and use of medicinal plants by the riparian of the São Francisco River. It also revealed the importance of other methodologies for scientific evidence for the popular use of R. echinus.
The method with the 324-gram mass dropped from a 70-cm height onto the gastrocnemius muscle of rats seems to be the most suitable for the production of muscle injury in these animals after 72 hours, showing an important inflammatory infiltrate.
Cuidado além da biomedicina: práticas integrativas e complementares para pacientes e acompanhantes do Hospital Universitário Da Univasf (HU-UNIVASF) Care beyond biomedicine: integrative and complementary practices por patients and accompanents of
A fitoterapia é utilizada há séculos e, até hoje, tem grande importância em muitas comunidades. Embora essa prática seja uma alternativa amplamente utilizada para o cuidado em saúde, com benefícios conhecidos de inúmeras espécies vegetais, a utilização inapropriada de plantas medicinais pode gerar graves problemas para a saúde de indivíduos. Por isso, são necessários estudos para analisar a utilização de plantas medicinais pela sociedade. Este trabalho procura realizar o estudo etnofarmacológico das plantas medicinais utilizadas em uma instituição de saúde holística na cidade de Petrolina, Pernambuco. Foram coletadas todas as plantas cultivadas na instituição que, no momento da coleta, apresentavam partes férteis, para a identificação da espécie botânica. Para coleta de dados sobre as plantas utilizadas pelos pacientes dessa instituição, foi realizada uma análise randomizada em 140 prontuários. Dentre as plantas indicadas, foram consideradas neste estudo apenas as que foram coletadas e identificadas taxonomicamente. As dez plantas mais indicadas foram comparadas com dados na literatura. As indicações para uso dessas plantas corroboram com estudos prévios que, contudo, avaliam apenas a utilização de uma planta durante as preparações para uso, desconsiderando possíveis interações que acontecem quando várias plantas são utilizadas em associação, prática comum na instituição pesquisada. A partir da pesquisa, considera-se que o saber popular é de grande importância para direcionar a descoberta de plantas com propriedades farmacológicas, tendo em vista que muitas indicações referidas através de conhecimento popular são comprovadas por estudos científicos.
Este artigo tem como objetivo relatar a experiência da implantação de um Centro de Referência em Práticas Integrativas e Complementares no Vale do São Francisco (CERPICS) que atua de forma indissociável com a pesquisa-ensino-extensão. Foram atendidas mais de 450 pessoas, com cerca de 2.500 atendimentos, através do apoio de voluntários. Na formação, foram realizadas atividades para profissionais vinculados ao Sistema Único de Saúde que encaminhavam os usuários aos CERPICS. No âmbito da pesquisa, foi possível traçar um perfil dos usuários, tomando como base dados socioeconômicos de 130 pessoas. A maior parte dos usuários tinha de 41 a 60 anos (60,2%), representando 89,5% de mulheres; 36,1% sem renda fixa ou com apenas 1 salário mínimo (33,8%), e 50,4% dos usuários fazendo uso diário de medicamentos controlados. Desafios no âmbito da assistência, formação e pesquisa perpassam o projeto, mas consideramos importante seguir trabalhando para uma mudança na cultura de cuidado.
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