In the critical period of neurodevelopment (gestation and lactation), maternal consumption of essential fatty acids (FAs) can alter the offspring cognitive function permanently causing damage. Lipids can regulate neurotrophin and compose brain tissue. However, the effects of maternal consumption of a mixture of conjugated linoleic acid (CLA) on an offspring nervous system are not completely clear. We aimed to investigate the impacts of different CLA concentrations mixed into the maternal diet during early life on neonatal reflex maturation and cognitive functions of the offspring. Three groups were formed: control (CG): receiving a standard diet; CLA1: receiving a diet containing 1% of CLA, and CLA3: receiving a diet containing 3% of CLA, offered during gestation and lactation. After birth, the reflex responses of the offspring were observed from the 1st to the 21st day. After weaning, the animals’ anxiety and memory were assessed using open field (OF) and novel object recognition tests. Fatty acids in the breast milk and the offspring’s brain were also quantified. The data were analyzed using one-way ANOVA and the Kruskal–Wallis test. CLA1 presented accelerated palmar grasp disappearance versus CLA3 and negative-geotaxis versus CG; and the CLA3 presented increases for most reflexes (cliff-avoidance, vibrissa-placing, negative-geotaxis, and auditory-startle response), and decrease in reflexes palmar grasp and free-fall righting versus CG ( p < 0.05). CLA3 group explored less of the OF in the second exposure. CLA1 and CLA3 presented an increased exploration ratio for new objects, which indicates memory improvement. The milk tested from CLA3 demonstrated an increase in polyunsaturated fatty acids (PUFAs), and a decrease in monounsaturated fatty acids. The amount of CLA in milk was greater in CLA1 and CLA3 and in the brain offspring both presented moderated amounts of CLA. Maternal treatment with the CLA mixture induced anticipated reflex maturation and improved memory in the offspring. Even though CLA was detected in the brains in only trace amounts, offspring’s brain PUFA and SFA levels were increased. Further studies aimed to delineate the effect of maternal CLA supplementation on offspring’s brain lipid metabolism and long-term neurologic outcome are needed to confirm these findings.

The objective of this study is to evaluate the effects of a diet with goat milk fat supplemented with physical training on markers of oxidative stress in the brain and anxiety behavior in rats. Adult male rats were randomly divided into six groups (n = 10 per group): control sedentary (CON) and exercised (CON-EX) groups, goat milk fat sedentary (GM) and exercised (GM-EX) groups, goat milk fat enriched with CLA sedentary (GM-CLA) and exercised (GM-CLA-EX) groups. The exercised groups were submitted to treadmill running during four weeks. Anxiety parameters were evaluated with the open field (OF) and elevated plus maze (EPM) tests. Malondialdehyde (MDA) and glutathione (GSH) levels were measured in the brain. Compared to the CON and GM groups, the GM-CLA group (p < 0.05), in which the animals were treated with goat milk fat with an increased CLA content, showed higher rearing. All exercised animals presented an increase in grooming when compared to sedentary animals. The number of entries in the open arms and time spent in the open arms was higher in sedentary groups (p < 0.05). MDA levels in the brain were lower in the GM group when compared to those in the CON group (p < 0.05). MDA increased in exercised animals (p < 0.05). GM and GM-CLA groups showed a significant elevation in the GSH levels in the brain. Goat milk fat, however, showed a potential effect on the reduction of oxidative stress, which was associated with a reduction in anxiety behavior. However, this beneficial effect was reversed when exercise was involved.

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Macaíba palm seed kernel is a source of lipids and phenolic compounds. The objective of this study was to evaluate the effects of macaíba palm seed kernel on anxiety, memory, and oxidative stress in the brain of health and dyslipidemic rats. Forty rats were used, divided into 4 groups (n = 10 each): control (CONT), dyslipidemic (DG), kernel (KG), and Dyslipidemic kernel (DKG). Dyslipidemia was induced using a high fat emulsion for 14 days before treatment. KG and DKG received 1000 mg/kg of macaíba palm seed kernel per gavage for 28 days. After treatment, anxiety tests were carried out using the Open Field Test (OFT), Elevated Plus Maze (EPM), and the Object Recognition Test (ORT) to assess memory. In the animals’ brain tissue, levels of malondialdehyde (MDA) and total glutathione (GSH) were quantified to determine oxidative stress. The data were treated with Two Way ANOVA followed by Tukey (p <0.05). Results demonstrated that the animals treated with kernel realized more rearing. DG and KG groomed less compared with CONT and DKG compared with all groups in OFT. KG spent more time in aversive open arms compared with CONT and DKG compared with all groups in EPM. Only DKG spent more time in the central area in EMP. KG and DKG showed a reduction in the exploration rate and MDA values (p <0.05). Data showed that macaíba palm seed kernel consumption induced anxiolytic-like behaviour and decreased lipids peroxidation in rats’ brains. On the other hand, this consumption by healthy and dyslipidemic animals compromises memory.

Patients affected by hypertension and/or diabetes mellitus may be susceptible to drug-nutrient interactions due to frequent use of medications and possible pharmacological associations. Therefore, the aim of this study was to investigate the possible drug-nutrient interactions – and their respective mechanisms of action – of antihypertensives and antidiabetics prescribed at the Alcides Carneiro University Hospital, as well as to present recommendations that assist health professionals and users in the proper management of these interactions. Therefore, a descriptive exploratory study of qualitative approach was carried out, using the technique of direct observation; which consisted of a contact with the pharmaceutical sector of the hospital to obtain information related to the prescribed drugs, and a subsequent survey in scientific articles, books and electronic bularia to identify their possible interactions with food in general, in addition to the mechanisms that permeate them. Among the total of 18 drugs prescribed for hypertension, important interactions were found for 83.3% (n=15), while of the 5 drugs for the treatment of diabetes, 100% (n=5) demonstrated to have interactions with some food/nutrient. The results contributed to further scientific clarification about the potential interaction of food/nutrients with antihypertensives and antidiabetics and will serve as a search tool for health professionals, especially HUAC, and other stakeholders.

Objetivo: avaliar o conhecimento de gestantes em relação à utilização de plantas medicinais no município de Cuité-PB. Metodologia: consiste em uma pesquisa de abordagem quantitativa, com tipologia descritiva e de corte transversal, realizada nas Estratégias Saúde da Família e Centro de Referência de Assistência Social no município de Cuité-PB, com 50 gestantes no período de fevereiro a março de 2019. Resultados: foi possível verificar o conhecimento das gestantes acerca das plantas medicinais utilizadas em geral, sua forma de aquisição, indicação, e seu uso no período gestacional, evidenciando riscos, contraindicações e orientações dos profissionais de saúde diante do tema. Desta forma, percebeu-se que o conhecimento científico deve prevalecer sobre o senso comum coletivo, devido à falta de informações seguras acerca da utilização de plantas como forma de tratamento, principalmente durante a gestação, visto que 36% das entrevistadas afirmaram ter orientação sobre esta prática durante o acompanhamento gestacional. Conclusão: portanto, compreender a visão das gestantes foi de grande relevância, uma vez que a utilização de plantas medicinais no período gravídico oferece riscos ao desenvolvimento fetal e à saúde materna. Por fim, a orientação por parte dos profissionais de saúde é imprescindível para prevenir riscos e agravos à saúde, fortalecendo e valorizando as Práticas Integrativas e Complementares no Sistema Único de Saúde.

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