Chemotherapy is a cornerstone option in cancer treatment owing to its efficacy and effect on quality of life of cancer patients. The action mechanism of anticancer agents is targeted at deregulating cell cycle machinery and inhibiting unscheduled proliferation of cancer cells (Lin et al., 2020). Unfortunately, chemotherapeutic anticancer drugs often exert deleterious effect on healthy cells and tissues leading to systemic toxicity (Negrette-Guzmán, 2019). The toxicity may become unbearable that the treatment regimen has to be disrupted, even when achieving tumoricidal efficacy (Lin et al., 2020). Cisplatin (CIS) is an efficacious anticancer agent; it is the first choice for the treatment of advanced nonsmall-cell lung cancer cells, breast cancer and ovarian cancer (Browning et al., 2017; Lin et al., 2020; Manohar & Leung, 2018). It is of significant value also in the treatment of germ cell and testicular cancers (Thurston, 2007). It unleashes its anticancer action through formation of cisplatin-DNA adduct by intrastrand cross-links due to interaction with cancer cell DNA purine bases eventually leading to p53 activation, cell cycle arrest and induction

This study accessed the dynamics of urogenital schistosomiasis transmission in Nkalagu Community. A total of 500 mid-day urine samples were collected and transported to Microbiology Laboratory, Ebonyi State University, for analysis. 10ml each of the urine samples was centrifuged at 2500 rpm for 5 minutes. Transmission potential of snail intermediate host of Schistosomes collected from different sampling station at the transmission sites within the study community was equally accessed. The snail species collected were placed individually into a clean beaker with little quantity of water and then subjected to shedding light for 2 hours. Data obtained were entered in excel spread sheet and analyzed using chi square test. The result obtained shows that 205 (41%) out of 500 individuals examined were excreting S. haematobium ova in their urine. The highest prevalence of infection (23%) was found among 11-20-year age groups. Males were more infected (25.4%) than their female counterparts (15.6%), although this was not statistically significant (p > 0.05). A total of 283 snails belonging to two Bulinus species (B. globosus and B. truncatus) were collected from the four sites sampled. Bulinus globosus recorded the highest species abundance (177) with the highest occurrence in site A. 52 (18.4%) out of 283 snails collected were infected with cercariae, and the highest cercariae infection (12.0%) was recorded among B. globosus. With prevalence of 41% among the human population and the prevalence of 18.4% patent infection among the snail intermediate hosts, urogenital schistosomiasis is still a public health problem in the study area and falls within the WHO classification of endemic area. Public health campaign is recommended in order to educate the people on the mode of transmission and control of the disease.

The investigation was carried out to determine the susceptibility of ABO blood groups to malaria parasiteamia among residents of Awka, Awka South L.G.A, Anambra State Nigeria. The research revealed that out of 309 samples analyzed for ABO blood groups susceptibility for malaria in various classes, 265 (85.8%) was observed to have patent parasiteamia with malaria. Among the sexes, males recorded higher susceptibility than females, with blood group B recording highest (94.5%) susceptibility of infection than other blood groups.The ABO and Rhesus blood group phenotype sample were determined by agglutination method using commercially provided antisera suitable for the detection of blood rhesus positivity and negativity.

The prevalence of urinary schistosomiasis among school age children in seven primary schools in Ebonyi North Senatorial district of Ebonyi State was investigated using standard parasitological technique. Out of 525 pupils examined, 119(22.7%) were found to be excreting ova of S. haematobium in their urine, which comprised 44 females (17.5%) and 75 males (27.5%). Children between the age of 15 -16 years recorded the highest prevalence of 35.9%. Chi square test showed that the differences among the age groups are not statistically significant. The distribution of the infection was significantly high in Hill Top Primary School Amoffia Ngbo, Ohaukwu Local Government Area with the prevalence of 55.3% when compared to other locations assayed. Children whose parents were farmers recorded the highest prevalence (26.4%) when compared to those of other occupations (p<0.05). In the same vein, children that make use of quarry pit water as their main source of water supply recorded more infection than those that use