Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Abstract

Chemotherapy is a cornerstone option in cancer treatment owing to its efficacy and effect on quality of life of cancer patients. The action mechanism of anticancer agents is targeted at deregulating cell cycle machinery and inhibiting unscheduled proliferation of cancer cells (Lin et al., 2020). Unfortunately, chemotherapeutic anticancer drugs often exert deleterious effect on healthy cells and tissues leading to systemic toxicity (Negrette-Guzmán, 2019). The toxicity may become unbearable that the treatment regimen has to be disrupted, even when achieving tumoricidal efficacy (Lin et al., 2020). Cisplatin (CIS) is an efficacious anticancer agent; it is the first choice for the treatment of advanced nonsmall-cell lung cancer cells, breast cancer and ovarian cancer (Browning et al., 2017; Lin et al., 2020; Manohar & Leung, 2018). It is of significant value also in the treatment of germ cell and testicular cancers (Thurston, 2007). It unleashes its anticancer action through formation of cisplatin-DNA adduct by intrastrand cross-links due to interaction with cancer cell DNA purine bases eventually leading to p53 activation, cell cycle arrest and induction

Panax ginseng’in sıçanlarda sisplatin ile oluşturulan testis hasarı üzerine etkileri

“…When gonadotropin luteinizing hormone is released, it results in cAMP release and protein kinase A activation, which initiates a series of enzyme cascade reactions (Liu et al, 2015). In various studies examining the effects of CP on testicular and reproductive function, it has been shown that plasma or testicular total and free testosterone levels are also reduced; these results have often been associated with oxidative stress (Azab et al, 2020;Ceylan et al, 2020;Famurewa et al, 2020;Jourabi et al, 2020;Kohsaka et al, 2020;Majd et al, 2021;Saad et al, 2020;. In the present study, we also demonstrated that CPinduced oxidative stress significantly decreased total and free testosterone levels in rats' plasma.…”

Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin

“…The absence of any notable action of LCP and CAPE on CP-induced increase in NO production might be related to the organ-specific action of 2 tested antioxidants, which has been reported for different natural compounds [18]. On the other hand, a decrease in NO production was found to be associated with an aggravation in CP-induced kidney damage [19], while an increase in its production and iNOS expression was associated with CP-induced peripheral neuropathy [20] and testicular tissue damage [21]. Thus, it might be difficult to predict what would be the most beneficial property of a drug/substance targeting the NO/iNOS mechanism in different organs affected by CP.…”

Antioxidant and Anti-inflammatory Properties Mediate the Neuroprotective Effects of Hydro-ethanolic Extract of Tiliacora triandra Against Cisplatin-induced Neurotoxicity

“…Previous studies have also reported loss of body weight due to injection of CDDP. 26,27 We observed that the intake of food by the rats reduced as well as the water intake. Conceivably, reduced food consumption occasioned by the CDDP may contribute to the loss of weight as energy expenditure may be greater than energy harvested during the reduced food intake.…”