The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in outbreak of global pandemic, fatal pneumonia in human referred as Coronavirus Disease-2019 (Covid-19). Ayurveda, the age old practice of treating human ailments in India, can be considered against SARS-CoV-2. Attempt was made to provide preliminary evidences for interaction of 35 phytochemicals from two plants (Phyllanthus amarus and Andrographis paniculata used in Ayurveda) with SARS-CoV-2 proteins (open & closed state S protein, 3CLpro, PLpro and RdRp) through in silico docking analysis. The nucleotide analogue remdesivir, being used in treatment of SARS-CoV-2, was used as a positive control. The results revealed that 18 phytochemicals from P. amarus and 14 phytochemicals from A. paniculata shown binding energy affinity/dock score < − 6.0 kcal/ mol, which is considered as minimum threshold for any compound to be used for drug development. Phytochemicals used for docking studies in the current study from P. amarus and A. paniculata showed binding affinity up to − 9.10 kcal/mol and − 10.60 kcal/mol, respectively. There was no significant difference in the binding affinities of these compounds with closed and open state S protein. Further, flavonoids (astragalin, kaempferol, quercetin, quercetin-3-O-glucoside and quercetin) and tannins (corilagin, furosin and geraniin) present in P. amarus have shown more binding affinity (up to − 10.60 kcal/mol) than remdesivir (up to − 9.50 kcal/mol). The pharmacokinetic predictions suggest that compounds from the two plants species studied in the current study are found to be non-carcinogenic, water soluble and biologically safe. The phytochemicals present in the extracts of P. amarus and A. paniculata might have synergistic effect with action on multiple target sites of SARS-CoV-2. The information generated here might serve as preliminary evidence for anti SARS-CoV-2 activity of phytochemicals present from P. amarus and A. paniculata and the potential of Ayurveda medicine in combating the virus.
:The experiment was conducted on powdery mildew of Chilli (Capsicum annuum L.) caused by Leveillulla taurica to know the effective management strategy. The pooled data revealed that there was significant effect of the treatments in reducing the disease. However, plants sprayed with Difenconazole (0.5g/L) as a second spray 15 days after the Chlorothalonil (2/L) was found to be effective in the management of powdery mildew, where in the PDI of 11.85 as against to control plot and also supported the higher yield of 13.4 t/ha in contrast to 9 t/ ha in untreated control plots.How to view point the article : Basha, C.R. Jahir, Soniya, M.C. and Ganiger, Prabhu C. (2017). Field evaluation of fungicides against powdery mildew of chilli (Capsicum annuum L.). Internat. J. Plant Protec., 10(2) : 329-332,
Background: Slag based gypsum (SBG) is a value-added product of iron and steel industry. Application of gypsum as source of calcium and sulphur for groundnut cultivation is common practice and mainly applied during peg initiation stage of groundnut. However, its effect is mainly influenced by the type of soil and dissolution of gypsum, which facilitates the yield and quality of groundnut. Hence, field experiments were conducted to know the effect of application of different rates of SBG as basal and split application on soil properties, yield, quality, nutrient use and uptake efficiency of groundnut in acidic soil. Methods: This study contains of seven treatments which includes recommended dose of fertilizer (RDF) with three levels of SBG (375, 500 and 625 kg ha-1) was applied as basal and split and 500 kg natural gypsum (NG) ha-1 was applied as basal dose according to package of practice (POP) of University of Agricultural Sciences, Bangalore by using randomly complete block design (RCBD) at Agricultural Research Station, Balajigapade during kharif 2018 and 2019. Result: The pooled data of two field experiments on groundnut revealed that application of RDF + 625 kg SBG ha-1 as 50% at sowing + 50% at peg initiation stage recorded higher pod (28.01 q ha-1), haulm (54.46 q ha-1), kernel (20.59 q ha-1), protein (89.70 q ha-1) and oil (7.06 q ha-1) yield when compared to other treatments. There was an increase in pod, haulm and oil yield of groundnut by 11.62, 20.59 and 17.99%, respectively with the split application of 625 kg SBG ha-1 (50% at sowing + 50% at 30 DAS) over NG applied treatments. Split application of SBG significantly increased the availability of nutrients in post harvest soils than basal application. Significantly higher S and Ca nutrient use efficiency (33.98 and 28.93 kg produce/kg S and Ca utilized, respectively) and uptake efficiency (0.39 and 1.29 kg kg-1, respectively) was recorded with the split application of SBG @ 375 kg ha-1.
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