The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in outbreak of global pandemic, fatal pneumonia in human referred as Coronavirus Disease-2019 (Covid-19). Ayurveda, the age old practice of treating human ailments in India, can be considered against SARS-CoV-2. Attempt was made to provide preliminary evidences for interaction of 35 phytochemicals from two plants (Phyllanthus amarus and Andrographis paniculata used in Ayurveda) with SARS-CoV-2 proteins (open & closed state S protein, 3CLpro, PLpro and RdRp) through in silico docking analysis. The nucleotide analogue remdesivir, being used in treatment of SARS-CoV-2, was used as a positive control. The results revealed that 18 phytochemicals from P. amarus and 14 phytochemicals from A. paniculata shown binding energy affinity/dock score < − 6.0 kcal/ mol, which is considered as minimum threshold for any compound to be used for drug development. Phytochemicals used for docking studies in the current study from P. amarus and A. paniculata showed binding affinity up to − 9.10 kcal/mol and − 10.60 kcal/mol, respectively. There was no significant difference in the binding affinities of these compounds with closed and open state S protein. Further, flavonoids (astragalin, kaempferol, quercetin, quercetin-3-O-glucoside and quercetin) and tannins (corilagin, furosin and geraniin) present in P. amarus have shown more binding affinity (up to − 10.60 kcal/mol) than remdesivir (up to − 9.50 kcal/mol). The pharmacokinetic predictions suggest that compounds from the two plants species studied in the current study are found to be non-carcinogenic, water soluble and biologically safe. The phytochemicals present in the extracts of P. amarus and A. paniculata might have synergistic effect with action on multiple target sites of SARS-CoV-2. The information generated here might serve as preliminary evidence for anti SARS-CoV-2 activity of phytochemicals present from P. amarus and A. paniculata and the potential of Ayurveda medicine in combating the virus.

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No therapeutics and vaccines are available against SARS-CoV-2 at present. In the current study we have made an attempt to provide preliminary evidences for interaction of 35 phytochemicals from two plants (<i>Phyllanthus amarus </i>and <i>Andrographis paniculata</i> used in Ayurveda<i>)</i> with SARS-CoV-2 proteins (S protein, 3CLpro, PLpro and RdRp) through <i>in silico</i> docking analysis. The docking was performed with the aid of AutoDock Vina and ADME and other pharmacokinetic properties were predicted using SWISSADME and admetSAR

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Embedding smart materials in the composite to enhance mechanical strength have become a research hotspot owing to their unique properties. The present research also focus on novel way to fabricate composite by embedding Shape Memory Alloy (SMA) wire and montmorillonite (MMT) nanoclay by varying clay concentration (0-7 wt.%). The extent of dispersion of nanoclay in epoxy resin was studied using Transmission Electron Microscopy (TEM) and X-ray diffraction (XRD). Fabricated samples were examined for tensile, flexural and impact characteristics. Scanning Electron Microscopy (SEM) was used to study the adhesion, delamination and damage occurred within the composite due to tensile loading. Results shows that the tensile strength, flexural strength and impact energy of SMA/MMT/glass/epoxy composite was improved by 23%, 21% and 57% respectively, when it was compared with composite with glass/epoxy composite.

No therapeutics and vaccines are available against SARS-CoV-2 at present. In the current study we have made an attempt to provide preliminary evidences for interaction of 35 phytochemicals from two plants (<i>Phyllanthus amarus </i>and <i>Andrographis paniculata</i> used in Ayurveda<i>)</i> with SARS-CoV-2 proteins (S protein, 3CLpro, PLpro and RdRp) through <i>in silico</i> docking analysis. The docking was performed with the aid of AutoDock Vina and ADME and other pharmacokinetic properties were predicted using SWISSADME and admetSAR