Our experience with radiosurgery of brain metastases is based on 160 patients with 235 tumors treated over a 16-year period. In this material, 94% growth control was achieved. Radiosurgery appears to be an effective, low-morbidity substitute for surgical resection followed by whole brain radiotherapy and even indicated for multiple metastases and distant new tumors. More patients receive an effective treatment with less neurologically related deaths.

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During the first 5 days after an intracranial haemorrhage, the red blood cells slowly haemolyse. Most of the oxyhaemoglobin, released in the cerebrospinal fluid, is transformed into bilirubin by an enzyme-dependent process. After 5 days, the haemolysis increases without a corresponding enhancement in the formation of bilirubin. Consequently, the oxyhaemoglobin concentration also increases. A spontaneous oxidation of the haem groups follows and after about 10 days the proportions of oxy- and methaemoglobin are about the same. This process occurs independently of the cause of the haemorrhage.

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