Gamma Knife Surgery for Cerebral Metastasis

Kihlström, Lars; Karlsson, Bengt; Lindquist, C.; Norén, Georg; Rähn, T.

doi:10.1007/978-3-7091-9160-6_25

Cited by 57 publications

(25 citation statements)

References 7 publications

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“…The rationale for applying SRT technique in RCC in extracranial metastatic lesions was the former good results using gamma-knife radiosurgery for brain metastases in RCC [9] and data indicating that selected patients benefit from surgical resection of singular metastases.…”

Section: Discussionmentioning

confidence: 99%

“…An important part in the methodology of SRT is to use CT for direct geometrical verification of the target position in the stereotactic system, instead of indirect verification of bony landmarks by portal imaging [9]. Thus, a new CT examination was done shortly before the first treatment to verify reproducibility.…”

Section: Geometrical Verificationmentioning

confidence: 99%

“…In several clinical studies however, brain metastases treated with gamma-knife radiosurgery have yielded a local control rate of 90% and survival times similar to those achieved by surgery Correspondence: Dr. Peter Wersäll, Dept of Gen Oncol, Radiumhemmet, Karolinska University Hospital, 17176 Stockholm, Sweden. E-mail: peter.Wersall@ karolinska.se [8,9]. Recently, the application of a similar radiation technique to extracranially located tumors has been made possible by the development of a stereotactic methodology for body targets enabling accurate localization of the tumor and optimal treatment with an accelerator [10,11].…”

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confidence: 99%

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A prospective Phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Section: Geometrical Verificationmentioning

confidence: 99%

mentioning

confidence: 99%

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A prospective Phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma

et al. 2006

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“…Some of the reports suggest the addition of radiosurgery to standard brain radiation may generate a clinical advantage of relieving the clinical symptoms [1,[6][7][8][9]. Stereotactic radiosurgery is currently used to treat patients who are not good candidates for conventional neurosurgical procedures.…”

Section: Introductionmentioning

confidence: 99%

Dose Volume Histogram Analysis of the Gamma Knife Radiosurgery Treating Twenty-Five Metastatic Intracranial Tumors

Yang

Ting

et al. 1998

Stereotact Funct Neurosurg

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Treating multiple brain metastatic sites in Gamma Knife radiosurgery is not uncommon. Most metastases can be treated with few or even one single shot. Occasionally we have patients returning for retreatment for different intracranial metastatic sites at different times. Dose distribution for these metastases are prescribed locally without considering the previous dose contribution. We present a study which simultaneously calculates the dose distribution of 25 randomly placed shots distributed inside the intracranial region. The Dose Volume Histogram (DVH) is plotted to study the coverage of the tumor sites and normal tissues. We have calculated ten DVH studies and show that 50% of the brain volume receives less than 500 cGy for the maximum tumor dose of 40 Gy, and the dose gradient is extremely steep. This DVH analysis shows that the Gamma Knife radiosurgery is a good treatment modality to control the local tumors while maintaining normal brain function, even for the large number of brain metastasis treated at different times.

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“…14) This method has been used in the treatment of a variety of intracranial lesions, including arteriovenous malformations, metastatic tumors, gliomas, pituitary adenomas, acoustic neurinomas, and meningiomas. 6,11,13,16,17) Experience in using radiosurgery for benign intracranial lesions is increasing. Irradiation-induced malignancy after exposure to radiosurgery is to be anticipated, but has so far been reported in only a few patients.…”

Section: Discussionmentioning

confidence: 99%

Intracranial Osteosarcoma After Radiosurgery-Case Report-

Sanno

Hayashi

Shimura

et al. 2004

Neurol. Med. Chir.(Tokyo)

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Fig. 1 T 1 -weighted magnetic resonance imagesshowing a mass lesion in the right frontoparietal parasagittal region, and with contrast medium showing a homogeneously enhanced lesion attached to the falx with so-called dural tail sign. AbstractA 56-year-old woman presented with an intracranial osteosarcoma at the site of previous radiosurgery, manifesting as sudden onset of headache and left hemiparesis with aphasia. She had a previous history of stereotactic radiosurgery for an intracranial tumor under a diagnosis of falx meningioma. Computed tomography showed intratumoral and peritumoral hemorrhage at the right parietofrontal region. Gross total resection of the tumor with hematoma was performed. The histological diagnosis was osteosarcoma. Sarcomatous change is a rare complication of radiotherapy. This case illustrates that osteosarcoma may develop years after radiosurgery for benign brain neoplasm.

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Gamma Knife Surgery for Cerebral Metastasis

Cited by 57 publications

References 7 publications

A prospective Phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma

A prospective Phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma

Dose Volume Histogram Analysis of the Gamma Knife Radiosurgery Treating Twenty-Five Metastatic Intracranial Tumors

Intracranial Osteosarcoma After Radiosurgery-Case Report-

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