The effects of the swine lymphocyte antigen (SLA) system on different performance traits were investigated in Swiss pig breeds. Litter size and piglet weight at birth and at weaning were considered and in gilts the average daily weight gain, backfat and muscle thickness as well as percentage valuable cuts were measured. These data were analysed with least squares procedures. Although the effect of SLA on these traits was very small, a few haplotypes seemed to have some influence. Sows of the Large White breed carrying H12 had a significant smaller and those with H24 had a bigger litter size at weaning. Some mating studies were performed to investigate the effects of SLA homozygosity. The obtained results suggest that this has a negative effect on the litter size, especially when H19 in the Large White breed and H7 in Landrace are involved.
The first international comparison test on swine lymphocyte alloantigens (SLA) was held in Helsinki, Finland in July 1986. The results reported were based on a comparison of 157 alloantisera originating from six laboratories. The antisera were tested against a selected panel of 264 lymphocyte samples belonging to four laboratories. The most common breeds in Europe were chosen for this first comparison test (Landrace and Large White). Eighteen of the 31 previously known specificities were confirmed and a new nomenclature was established.
Restriction fragment length polymorphism (RFLP) analyses of swine leukocyte antigen (SLA) class I and class II genes from Swiss Large White and American Hampshire families were performed using porcine DNA probes. Class I and class II RFLPs associated with the serologically-defined haplotypes SLA H1, H8, H16 and H24 and with serotypes SLA 15, 16; SLA 14; and SLA 6, SB 19, were identified. Seven allelic class I RFLP patterns were observed. For genes in the SLA class II region, six allelic RFLP patterns of DQA and DQB; five allelic RFLP patterns of DRA; and seven allelic RFLP patterns of DRB were observed. The serologicallydefined H8 haplotype was subtyped based on differences in class II RFLPs.
Summary Enzootic Pneumonia (EP) and Osteochondrosis dissecans (Oc) were investigated in relation to the swine histocompatibility complex (SLA). Animals of the Swiss Large White breed in the Pig Performance Testing Station were typed for SLA and examined for EP and Oc at slaughter. The statistical evaluation was analysed in a logistic regression model. A weak association between SLA and resistance to EP was registered. Pathological changes in the distal epiphuge of the ulna appeared to be associated to SLA. As the material was a random sample of the Swiss pig population, some SLA haplotype were hardly or not at all present in our study, which means that the results need to be confirmed by independent future studies. Zusammenfassung Mögliche Assoziation zwischen dem Haupthistokompatibilitätskomplex beim Schwein und der enzootischen Pneumonie sowie der Osteochondrosis dissecans In dieser Studie wurde die Beziehung zwischen dem Schweinehistokompatibilitätskomplex (SLA) und der enzootischen Pneumonie (EP) sowie der Osteochondrosis dissecans (Oc) untersucht. Edelschweine der Mast‐ und Schlachtleistungsprüfanstalt wurden SLA typisiert und die Schlachtkörper auf EP‐ und Oc‐Läsionen diagnostiziert. Die statistische Auswertung erfolgte mit einer logistischen Regressionsanalyse. Zwischen SLA und EP konnte eine schwache Beziehung ermittelt werden. Pathologische Veränderungen in der distalen Epifuge der Ulna scheint mit SLA assoziiert zu sein. Da das Untersuchungsmaterial nur eine kleine Stichprobe der schweizerischen Schweinepopulation darstellt, sind einige SLA Haplotypen nicht oder nur vereinzelt vorhanden. Die erzielten Resultate sollten deshalb in einer unabhängigen Studie bestätigt werden. Resumé Association possible entre le complexe majeur d'histocompatibilité porcin et la pneumonie enzootique et l'ostéochondrosis dissecans La pneumonie enzootique (EP) et l'ostéochondrosis dissecans (Oc) ont été étudiées en relation avec le complexe majeur d'histocompatibilité (SLA). Les porcs de la race Large White Suisse de la station de testage de performance ont été typisés pour le SLA et les lésions causées par l'EP et l'Oc ont été examinées sur les carcasses. L'evaluation statistique a été réalisé au moyen d'un modèle de regression logistique. Une faible correlation a été observée entre le système SLA et la resistance à l'EP. Des modifications pathologiques du carilage épiphysaire distal du cubitus semblent être associées au systéme SLA. Le materiel ne représentant qu'un échantillon aléatoire de la population porcine suisse, quelques haplotypes de SLA ne sont que peu ou pas du tout représentés dans cette étude, ce qui implique que ces résultats doivent être confirmés par une étude ulterieure.
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