and Chain, 1960) discovered a method of producing this compound on a large scale and made possible for the first time the synthesis of innumerable penicillin compounds. The first compound to stem from this research was phenethicillin (Broxil) an acid-stable preparation and hence suitable for oral administration. This preparation gives blood levels some two to three times higher than those obtained with penicillin V and as high or higher than those obtained with intramuscular injections of penicillin G. Unfortunately, however, this compound is eight times less effective in vitro against the gonococcus than is penicillin G., and various clinical trials gave disappointing results, the failure rate being as high or higher than with the earlier oral preparation penicillin V.
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