Streptomycin Resistant Gonorrhoea

Repeated Exposition to Subinhibitory Concentrations of Antibiotic in vitro Readily Decreases Susceptibility of <i>Neisseria gonorrhoeae </i>to Rifampicin, but Not to New Cephalosporins and Penicillin G

“…When introducing a new type of anti biotic into the therapy of gonorrhea one has to face the possibility of rapid devel opment of resistance; this especially has proven true in the case of streptomycin [Alergant, 1958]. Resistance to this anti biotic develops according to the faculta tive one-step type [Zinsser,I960].…”

“…Yet rapid increase of resistance made this kind of therapy unreliable with in a few years [Campbell, 1944]. The same happended with streptomycin [Alergant, 1958]. So it seems advisable to try to pre dict the development of resistance of a new antibiotic before introduction into large-scale use for a certain indication.…”

Treatment Problems of Gonorrhoea

“…Use of other antibiotics (a) Streptoniycin. Although gonorrhoea responds to single injections of 0.5-1.0 g of streptomycin (Lodin, 1956a) there have been increasing failure rates also with this drug (Alergant, 1958;and see Table 5). Cases have been reported which have been completely resistant to streptomycin (Ryan, 1952;Zierz & Jacob, 1954;Artemev & Gadzhiev, 1956;Davey, 1957).…”

Treatment of Non-Gonococcal Urethritis with Intramuscular Tetracycline (Terramycin)

“…The trial reported below was undertaken at a time when a degree of penicillin resistance was being reported in the treatment of gonococcal urethritis (King, 1958; Curtis and Wilkinson, 1958). The continued success of streptomycin in gonorrhoea was also questioned (Alergant, 1958).…”

“…The continued success of streptomycin in gonorrhoea was also questioned (Alergant, 1958). At this time, therefore, a need to treat gonorrhoea with a different antibiotic seemed likely to arise.…”