This combination of multiple congenital abnormalities has not been previously described and probably represents a new autosomal recessive syndrome involving a genetic abnormality that interferes with normal islet development and whose aetiology is as yet unknown.

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Anticardiolipin antibodies (ACA) were determined by an ELISA assay in 142 VDRL-positive patients who were classified in two groups: group I consisted of 77 patients with syphilis and group II of 65 patients with biological false-positive reaction in the standard test for syphilis. In group I 10% had ACA versus 52% in group II (p < 0.0001). Isotype distribution in group II showed a predominance of IgG. These results suggest that antiphospholipid antibodies in VDRL and ACA tests have different specificities.

Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. Methods. A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October 2017. After informed consent through the signature of a consent form was obtained, the plasma was collected to determine the lipid profile while the lysate solution of RBC was used to explore some markers of oxidative stress using spectrophotometric methods. Results. Among the 85 patients included in our study, the mean age was 30 ± 5 years and the female to male ratio was 0.97. The majority of the patients (52–81%) had dyslipidaemia, and 22.4% of the patients demonstrated a higher level of atherogenic index of plasma. The patients with a higher level of total cholesterol (TC) (>240 mg/dl) and low-density lipoprotein (LDL-C) (>159 mg/dl) had at least 1,334 fold of malondialdeheyde (MDA) concentration than those with normal level. Also in the same patients, the higher atherogenic plasmatic index (API) significantly (p<0.05) increased with the concentration of MDA. Except HDL-C, the other parameters of lipid profile had significant (p<0.05) correlation with reduced glutathione (GsH) and total antioxidant capacity (TAC). The significant (p<0.05) and linear regression was found between the increased MDA and higher API. Conclusion. Dyslipidemia increases oxidative stress and higher API which leads to coronary vascular disease in patients with SCA.