Ronidazole-14C was administered to turkeys in diets containing 0.003-0.008% of drug. More than 80 % of administered radioactivity was excreted and 1-2% was exhaled as 14C02. Metabolites were 2hydroxymethyl-l-methyl-5-nitroimidazole in trace amounts. Also found were A-methylglycolamide, methylamine, and oxalic acid. Radioactivity in tissues was associated with a number of normal body metabolites, such as glutamic and aspartic acids and citric acid cycle intermediates. The presence of acetyl-14C was demonstrated in urine and liver tissue. Radioactive protein, nucleic acid, and lipid fractions were found in whole liver, leading to the conclusion that extensive biodegradation of ronidazole-14C allows the recombination of carbon-14 into body metabolites.
While investigating the physiological disposition of the new drug ~-0-ethyl-14C-threonine in chicks, a high level of radioactivity was observed in muscle and moderate levels in other tissues. The nature of this radioactivity in muscle was further explored by fractionating the muscle tissue into RNA, DNA, lipid, glycogen, and proteins. Most of the radioactivity was found to be associated with proteins. The protein fraction was subjected to intensive investigation
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