Incorporation of L-O-ethylthreonine into chick muscle protein

Hiremath, C. B.; Olson, Gregory J.; Rosenblum, Charles

doi:10.1021/bi00782a025

Cited by 6 publications

(1 citation statement)

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“…A rather rare case (Hiremath et al, 1971) of direct incorporation into tissue is that of L-0-ethyl-[1-l4 C]threonine, which is an isoleucine antagonist, and is incorporated intact in muscle protein when fed in capsules (7.5 mg dose; specific activity =0.15 juCi/mg) to chicks. Three days after dosing, muscle still contained =70% of the ingested radioactivity.…”

Section: L-o-ethylthreonine (Oet)mentioning

confidence: 99%

Non‐drug‐related residues in tracer studies

Rosenblum

1977

Journal of Toxicology and Environmental Health

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Factors involved in residue studies with radioactive tracers are discussed. Three types of metabolic management of 14 C-labeled compounds are described. Intact incorporation into protein of chick muscle is demonstrated with L-O-ethyl-[ 14 C/threonine. Retention of unchanged and quantitatively recoverable parent compound occurred with [ 14 C] thiabendazole sprayed on oranges. The latter drug fed to animals was retained in tissue partly intact, but mostly metabolized to recognizable detoxification products, and ultimately to endogenous tissue components. The latter type of residue was termed a "nonmetabolite" residue. The extreme case of extensive metabolism to products structurally unrelated to the parent compound was illustrated with [ 14 C] ronidazole administered to turkeys.

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Section: L-o-ethylthreonine (Oet)mentioning

confidence: 99%