The possible nature of the biological activity of tenuazonic acid, a compound isolated from the culture filtrate of Alternaría, was investigated in vivo with intact rats and in vitro with Ehrlich ascites tumor and rat liver cells. The results obtained demonstrated that the new antibiotic inhibited the incorporation in vivo and in vitro of amino acids into proteins. Studies with cellfree systems have indicated that the inhibition by tenuazonic acid of protein synthesis was due essentially to the suppression of release of newly formed microsomal proteins into the supernatant fraction.Kaczka et al. (1963) isolated from the filtrate of Alternaría a material that exhibited growth-inhibitory action against human tumors growing in the embryonated egg. The compound was found to be identical Number SA-43-ph-1886.
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