The thermal stability of 1 M LiPF 6 solutions in mixtures of ethylene carbonate, diethyl carbonate, and dimethyl carbonate in the temperature range of 40 to 350°C was studied by accelerating rate calorimeters ͑ARC͒ and differential scanning calorimeters ͑DSC͒. Nuclear magnetic resonance ͑NMR͒ was used to analyze the condensed reaction products at different reaction stages. Studies by DSC and pressure measurements during ARC experiments with LiPF 6 solutions detected a gas-releasing endothermic reaction starting at ϳ170°C, involving diethyl carbonate which occurs before a number of exothermic reactions, which follow as the temperature increases. Fluoride ions are released and react with the alkyl carbonate molecules both as bases and as nucleophiles. The bulk analysis by NMR shows that HO-CH 2 -CH 2 -OH, FCH 2 CH 2 -OH, F-CH 2 CH 2 -F, and polymer are major products. Gas analysis by NMR and Fourier transform infrared spectroscopy shows PF 5 , CO 2 , CH 3 F, CH 3 CH 2 F, and H 2 O as major gaseous products of the thermal reaction of these solutions.

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A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2-halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.Key words: alkynes, selenium, oxidation, spiro compounds, diols Glutathione peroxidase (GPx) is a selenoenzyme that protects cells by catalyzing the reduction of peroxides with the stoichiometric reductant glutathione. 1The enzyme catalytic site includes a selenocysteine residue in which the selenium undergoes a redox cycle involving the selenolate anion as the active form, which reduces hydroperoxides. The selenol is first oxidized to a selenenic acid EnzSeOH, which reacts with reduced glutathione GSH to form the selenyl sulfide EnzSeSG. A second glutathione then regenerates the active form of the enzyme by attacking the EnzSeSG to form the oxidized glutathione GSSG. The overall catalytic cycle is depicted in Figure 1. Ebselen [2-phenyl-1,2-benzoisoselenazol-3(2H)-one] has been known as a mimetic of glutathione peroxidase (GPx), able to interact with active oxygen species present in living cells. [3][4][5][6] However, its use under nonenzymic conditions as a catalyst for hydrogen peroxide oxidation of thiols to disulfides gave poor results. Recently, Back et al. 7,8 have demonstrated the exceptional glutathione peroxidase-like activity of the simple bis(3-hydroxypropyl) selenide and the unexpected role of its oxidation product, spirodioxaselenanone, as an intermediate in the catalytic redox cycle for GPx.In view of the known role of organoselenium compounds in biological systems, [9][10][11][12] in addition to their unique characteristics in organic synthesis, 13 the design and synthesis of novel organoselenium compounds with potential biological activity constitutes an ongoing challenge. Recently, we have found that in situ prepared selenium dichloride, readily obtained from elemental selenium and sulfuryl chloride, 14 undergoes smooth 1,2-addition to the triple bond of various propargylic alcohols resulting in the formation of symmetrical (Z,Z)-bis(1-hydroxymethyl-2-chlorovinyl) selenides 1 in high yields and in completely regio-and stereospecific manner (Scheme 1). 15,16Of special mechanistic interest is the observed syn-addition and anti-Markovnikov orientation.Scheme 1 Regio-and stereospecific synthesis of functionalized divinyl selenides Inspired by the above findings, we applied our regio-and stereospecific SeCl 2 addition protocol in the planned preparation of novel GPx-mimetics of spirodioxaselenurane type. 8Those divinyl selenides formed by syn-addition of SeCl 2 to the triple bond, which do not bear a vicinal hydrogen capable of cis elimination, gave stable selenoxides 2a,b and selenone 3 in good yield upon oxidation with tert-butyl hydroperoxide or with 2 equivalents of MCPBA, respectively (Scheme 2). The divinyl s...

A convenient method to incorporate selenium into an organic molecule is reported. Various aspects of the reaction of SeCl2 with propargyl alcohols, i.e., identity of reacting functionality, regiospecificity, and stereospecificity, differ from expectations based on known reactions of these alcohols with SCl2. Selenium dihalides undergo smooth 1,2‐addition to the triple bond of various propargylic alcohols resulting in the formation of the corresponding functionalized divinyl selenides in high yields and with complete regio‐ and stereospecificity. Of special mechanistic interest is the syn‐addition and anti‐Markovnikov orientation observed in all cases. Copyright © 2010 John Wiley & Sons, Ltd.