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A comprehensive continuum model of solid tumor evolution and development is investigated in detail numerically, both under the assumption of spherical symmetry and for arbitrary two-dimensional growth. The level set approach is used to obtain solutions for a recently developed multi-cell transport model formulated as a moving boundary problem for the evolution of the tumor. The model represents both the avascular and the vascular phase of growth, and is able to simulate when the transition occurs; progressive formation of a necrotic core and a rim structure in the tumor during the avascular phase are also captured. In terms of transport processes, the interaction of the tumor with the surrounding tissue is realistically incorporated. The two-dimensional simulation results are presented for different initial configurations. The computational framework, based on a Cartesian mesh/narrow band level-set method, can be applied to similar models that require the solution of coupled advection-diffusion equations with a moving boundary inside a fixed domain. The solution algorithm is designed so that extension to three-dimensional simulations is straightforward.

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An experimental study has been carried out to examine double-diffusive convection in a porous medium. The experiments were performed in a horizontal layer of porous medium consisting of 3 mm diameter glass beads contained in a box 24 cm × 12 cm × 4 cm high. The top and bottom walls were made of brass and were kept at different constant temperatures by separate baths, with the bottom temperature higher than that of the top. The onset of convection was detected by a heat flux sensor and by the temperature distribution in the porous medium. When the porous medium was saturated with distilled water, the onset of convection was marked by a change in slope of the heat flux curve. The temperature distribution in the longitudinal direction in the middle of the layer indicated a convection pattern consisting of two-dimensional rolls with axes parallel to the short side. This pattern was confirmed by flow visualization. When the porous medium was saturated with salinity gradients of 0.15% cm−1 and 0.225% cm−1, the onset of convection was marked by a dramatic increase in heat flux at the critical ΔT, and the convection pattern was three-dimensional. When the temperature difference was reduced from supercritical to subcritical values, the heat flux curve established a hysteresis loop. Results from linear stability theory, taking into account effects of temperature-dependent viscosity, volumetric expansion coefficients, and a nonlinear basic state salinity profile, are discussed.

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