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Topical 5 percent 5-fluorouacil therapy is a safe and effective method to treat anal Bowen's disease. Wide local excision is appropriate for smaller, isolated areas of disease. Anal Bowen's disease was not associated with colonic or other neoplasms.

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Colonic histoplasmosis is a rare entity. There have been four previous reported cases within the population of patients with human immunodeficiency virus (HIV) infection. Because of the increasing incidence of HIV infection within regions where histoplasmosis is endemic, this condition may become more common. Gastrointestinal histoplasmosis has protean clinical manifestations, and symptoms are often nonspecific. Any patient with HIV infection who has unexplained GI symptoms should undergo evaluation for possible histoplasmosis. Aggressive long-term amphotericin B therapy has been effective in HIV patients with histoplasmosis. Resection or diversion of symptomatic colonic strictures caused by histoplasmosis may be necessary in addition to medical therapy.

Arterial blood studies were performed on 44 premature infants while in atmosphere and greater concentrations of oxygen. Analyses were made for oxygen content, oxygen capacity and hematocrit. Concomitant plethysmographic studies were made on 29 occasions. Results were as follows: 1. Only 25% (7) of the premature infants studied breathed regularly in atmosphere; the remaining individuals breathed with some degree of periodicity (44%) or completely irregularly (30%). 2. As the concentration of oxygen being breathed was raised, then more of the group shifted to a regular type of respiration until when in 75-85% oxygen, 88% of the group then breathed with a regular type of respiration. 3. a. The percentage arterial oxygen saturation of the group averaged 93% in atmosphere, 96% in 30-55% oxygen, 100% saturation in 70-79% oxygen being breathed and 102% in 80-89% oxygen. b. In atmosphere, when compared on age basis, the younger group (1-14 days) had essentially the same arterial oxygen saturation as the older group (14-65 days). In an atmosphere of 70-90% oxygen, the saturation of the younger group increased to 102% while the older group rose to 100%. c. When compared on body weight basis, the 0.9-1.3 kg. group increased the arterial oxygen saturation of 85% in atmosphere to 102% when 70-85% oxygen was administered; the 1.3-1.8 kg. group, 93% to 101%; the 1.8-2.3 kg. group, 9% to 100%. (It is noted that either on age or body weight basis the group with higher hematocrit attained higher arterial oxygen saturation when 70-85% oxygen was administered than the group with lower hematocrit.) 4. a. A statistical analysis of the respiratory records revealed an average rise of 30% in minute volume when 30-40% oxygen was administered, this rise being significantly maintained as higher concentrations (to 90%) of oxygen were administered. b. An average significant rise in respiratory rate of 30% was noted when 30-40% oxygen was administered which slowly fell to the original rate level as oxygen administered was increased to 80-90% concentration. c. Consequently, the tidal volume (volume per respiration) gradually increased to 30% above the level in atmosphere as oxygen administered was increased to 80-90% concentration.

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Deep vein thrombosis and its complications, including pulmonary embolism, are major health problems in the United States, resulting in more than 260,000 hospital admissions and 100,000 deaths each year. Thirty percent of patients diagnosed with deep vein thrombosis will experience at least one recurrence of symptoms. To minimize patient morbidity and mortality and to contain health care costs, prevention, early diagnosis, and treatment of these conditions are essential. In this article the incidence pathophysiology risk factors, and clinical course of deep vein thrombosis and pulmonary embolism are discussed, as well as the clinician's role in prevention and treatment.

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